Concomitant administration of pentoxifylline and theophylline may increase theophylline levels in some patients. Therefore there may be an increase in and intensification of adverse effects of theophylline. Concomitant administration with ciprofloxacin may increase the serum concentration of pentoxifylline in some patients.

Therefore, there may be an increase in and intensification of adverse reactions associated with co-administration. Visible inflammation commonly is minimal.

Chronic lesions--hyperpigmentation may be an occasional sequela, especially in black Miniature Poodles and other breeds that tend to respond to inflammation by hyperpigmentation. Sites--neck and shoulder region near the scapula where most subcutaneous rabies vaccinations are given.

Gravitational drift may result in lesions ventral to vaccination site. Systemic signs--a small subgroup of dogs display lethargy, depression, and fever. Elevated liver enzymes have been noted. Systemic signs may precede the skin lesion or occur concomitantly. Diagnosis--history of vaccination, compatible skin lesions, confirmatory skin biopsy.

Prognosis--most lesions remain small and are asymptomatic. Exacerbation has been observed after revaccination. Long-haired toy or miniature breeds seem to be at greater risk.

Clinical skin lesions--individual lesions are those of DM and DM-like disease but may be more severe and more generalized. More severe lesions are located over bony prominences and on distal extremities. Similar, but usually less severe lesions are seen over much of the skin surface. Muscle atrophy--variable, but may be marked. Prognosis--generalized vaccine-induced ischemic dermatopathy may gradually diminish in severity over time.

Dogs with GIID usually exhibit lifelong disease with some cyclical recrudescence. Revaccination can exacerbate disease. Other reported Ischemic Dermatopathies 1.

Other syndromes have been reported that share features with cell-poor vasculopathies and ischemic dermatopathies. Reported diseases include familial cutaneous vasculopathy of German Shepherd Dogs, and cutaneous vasculitis in Jack Russell Terriers. Familial cutaneous vasculopathy of German Shepherd Dogs is a rare vascular disease affecting predominantly the pawpads of German Shepherd Dog puppies. Pedigree analysis indicated probable autosomal recessive inheritance. Most published cases 26 dogs were seen in Canada, with another from the United States, and another from Italy.

Immunologic attack on collagen has been hypothesized as a mechanism. A temporal association with puppy vaccination and recrudescence with repeat vaccination was seen in some of the dogs, similar to some ischemic dermatopathies.

Clinical features--the prime clinical feature is depigmented, swollen pawpads. Erosions, ulceration, and hair loss with adherent crusting occur. Sites--pawpads are affected preferentially. Similar lesions may be present on the pinnae, tail tip, and nasal planum. Who should NOT take this medication?

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