Mothers receiving clonazepam should not breast-feed their infants. Safety and effectiveness in pediatric patients with panic disorder below the age of 18 have not been established. Clinical studies of clonazepam did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients.

In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.

Because clonazepam undergoes hepatic metabolism, it is possible that liver disease will impair clonazepam elimination. Sedating drugs may cause confusion and over-sedation in the elderly; elderly patients generally should be started on low doses of clonazepam and observed closely. Enter section text here Clonazepam is available as a tablet.

The tablets should be administered with water by swallowing the tablet whole. The initial dose for adults with seizure disorders should not exceed 1. Dosage may be increased in increments of 0. Maintenance dosage must be individualized for each patient depending upon response.

Maximum recommended daily dose is 20 mg. The use of multiple anticonvulsants may result in an increase of depressant adverse effects.

This should be considered before adding clonazepam to an existing anticonvulsant regimen. Clonazepam is administered orally. In order to minimize drowsiness, the initial dose for infants and children up to 10 years of age or 30 kg of body weight should be between 0. Dosage should be increased by no more than 0. Whenever possible, the daily dose should be divided into three equal doses. If doses are not equally divided, the largest dose should be given before retiring. There is no clinical trial experience with clonazepam in seizure disorder patients 65 years of age and older.

The initial dose for adults with panic disorder is 0. To reduce the inconvenience of somnolence, administration of one dose at bedtime may be desirable. It is important to note that anticonvulsant drugs should not be discontinued in patients in whom the drug is administered to prevent seizures because of the strong possibility of precipitating status epilepticus with attendant hypoxia and threat to life.

In individual cases where the severity and frequency of the seizure disorder are such that the removal of medication does not pose a serious threat to the patient, discontinuation of the drug may be considered prior to and during pregnancy; however, it cannot be said with any confidence that even mild seizures do not pose some hazards to the developing embryo or fetus.

General Concerns About Benzodiazepines An increased risk of congenital malformations associated with the use of benzodiazepine drugs has been suggested in several studies. There may also be non-teratogenic risks associated with the use of benzodiazepines during pregnancy. There have been reports of neonatal flaccidity, respiratory and feeding difficulties, and hypothermia in children born to mothers who have been receiving benzodiazepines late in pregnancy.

In addition, children born to mothers receiving benzodiazepines late in pregnancy may be at some risk of experiencing withdrawal symptoms during the postnatal period. Advice Regarding the Use of Klonopin in Women of Childbearing Potential In general, the use of Klonopin in women of childbearing potential, and more specifically during known pregnancy, should be considered only when the clinical situation warrants the risk to the fetus.

The specific considerations addressed above regarding the use of anticonvulsants for epilepsy in women of childbearing potential should be weighed in treating or counseling these women. Because of experience with other members of the benzodiazepine class, Klonopin is assumed to be capable of causing an increased risk of congenital abnormalities when administered to a pregnant woman during the first trimester. Because use of these drugs is rarely a matter of urgency in the treatment of panic disorder, their use during the first trimester should almost always be avoided.

The possibility that a woman of childbearing potential may be pregnant at the time of institution of therapy should be considered. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.

Patients should also be advised that if they become pregnant during therapy or intend to become pregnant, they should communicate with their physician about the desirability of discontinuing the drug. Precautions General Worsening of Seizures When used in patients in whom several different types of seizure disorders coexist, Klonopin may increase the incidence or precipitate the onset of generalized tonic-clonic seizures grand mal.

This may require the addition of appropriate anticonvulsants or an increase in their dosages. The concomitant use of valproic acid and Klonopin may produce absence status. Laboratory Testing During Long-Term Therapy Periodic blood counts and liver function tests are advisable during long-term therapy with Klonopin.

Risks of Abrupt Withdrawal The abrupt withdrawal of Klonopin, particularly in those patients on long-term, high-dose therapy, may precipitate status epilepticus. Therefore, when discontinuing Klonopin, gradual withdrawal is essential. Cross-tolerance occurs between benzodiazepines, meaning that, if individuals are tolerant to one benzodiazepine, they will display a tolerance to equivalent doses of other benzodiazepines.

Withdrawal symptoms from benzodiazepines include a worsening of pre-existing symptoms as well as the appearance of new symptoms that were not pre-existing. The withdrawal symptoms may range from mild anxiety and insomnia to severe withdrawal symptoms such as seizures and psychosis.

Withdrawal symptoms can be difficult in some cases to differentiate between pre-existing symptoms and withdrawal symptoms. Use of high doses, long-term use and abrupt or over-rapid withdrawal increases increase the severity of withdrawal syndrome.

Withdrawal from benzodiazepines should be gradual as abrupt withdrawal from high doses of benzodiazepines may cause confusion , toxic psychosis , convulsions , or a condition resembling delirium tremens.

Nothing Found

The concomitant use of valproic acid and clonazepam may produce absence status. Patients should be instructed to take Klonopin only klonopin prescribed. This should be considered before giving the drug to patients who have difficulty handling secretions. It has a molecular weight of Periodic blood counts and klonopin function tests are advisable during long-term therapy with clonazepam. Cross-tolerance occurs between benzodiazepines, meaning that, klonopin 7.5mg, if individuals are tolerant to one benzodiazepine, they 7.5mg display a tolerance to equivalent doses of other benzodiazepines. Withdrawal symptoms from benzodiazepines include a worsening of pre-existing symptoms as well as the appearance of new 7.5mg that were not pre-existing. Confusion, depression, 7.5mg, hallucinations, klonopin 7.5mg, hysteria, increased libido, insomnia, psychosis the behavior effects klonopin more likely to occur 7.5mg patients with a history of psychiatric disturbances. Chemically, clonazepam is 5- 2-chlorophenyl -1,3-dihydronitro-2H-1,4-benzodiazepinone, klonopin 7.5mg. Because klonopin undergoes hepatic 7.5mg, it is possible that liver disease will impair clonazepam elimination. Hepatomegaly, klonopin 7.5mg, transient elevations of 7.5mg transaminases and alkaline phosphatase Panic Disorder Adverse events during exposure to clonazepam were obtained by spontaneous report and recorded by clinical investigators using terminology of their own choosing, klonopin 7.5mg. Metabolites of clonazepam are excreted by the kidneys; to avoid their excess accumulation, caution should be exercised in the administration of the drug to patients with impaired renal function. While clonazepam is being gradually withdrawn, klonopin 7.5mg, the simultaneous substitution of another anticonvulsant may klonopin indicated. Limit dosage and duration klonopin concomitant klonopin of benzodiazepines and opioids, klonopin 7.5mg, and follow patients closely 7.5mg respiratory depression and sedation. Seizure Disorders The most frequently occurring side effects of clonazepam are referable to CNS depression.

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