This has been demonstrated in vitro; however, the clinical significance of this interaction is not well documented. Following administration of ampicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted.
This effect may also occur with Amoxicillin. Carcinogenesis, Mutagenesis, Impairment Of Fertility Long-term studies in animals have not been performed to evaluate carcinogenic potential.
Studies to detect mutagenic potential of Amoxicillin alone have not been conducted; however, the following information is available from tests on a 4: Amoxicillin and potassium clavulanate was non-mutagenic in the Ames bacterial mutation assay, and the yeast gene conversion assay. Amoxicillin and potassium clavulanate was weakly positive in the mouse lymphoma assay, but the trend toward increased mutation frequencies in this assay occurred at doses that were also associated with decreased cell survival.
Amoxicillin and potassium clavulanate was negative in the mouse micronucleus test, and in the dominant lethal assay in mice. Potassium clavulanate alone was tested in the Ames bacterial mutation assay and in the mouse micronucleus test, and was negative in each of these assays. Reproduction studies have been performed in mice and rats at doses up to 10 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to Amoxicillin.
There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Labor and Delivery Oral ampicillin-class antibiotics are poorly absorbed during labor. Studies in guinea pigs showed that intravenous administration of ampicillin slightly decreased the uterine tone and frequency of contractions but moderately increased the height and duration of contractions.
However, it is not known whether use of Amoxicillin in humans during labor or delivery has immediate or delayed adverse effects on the fetus, prolongs the duration of labor, or increases the likelihood that forceps delivery or other obstetrical intervention or resuscitation of the newborn will be necessary.
Nursing Mothers Penicillins have been shown to be excreted in human milk. Amoxicillin use by nursing mothers may lead to sensitization of infants. Caution should be exercised when Amoxicillin is administered to a nursing woman.
Pediatric Use Because of incompletely developed renal function in neonates and young infants, the elimination of Amoxicillin may be delayed. Geriatric Use An analysis of clinical studies of Amoxicillin was conducted to determine whether subjects aged 65 and over respond differently from younger subjects. To treat an infection, you should usually take one mg capsule three times a day.
In more severe infections, the dose may be increased to mg three times a day. For very severe respiratory infections, a very high dose of up to twelve mg capsules 6 g may be needed. For urinary tract infections one dose of six mg capsules 3 g may be given and repeated after hours.
For gonorrhoea a single dose of six mg capsules 3 g may be given. Children up to 10 years of age: The doctor will advise you of the dose, which could be up to one mg capsules 3 times a day in severe infections.
Children may be given a liquid preparation of amoxicillin instead of capsules. Your pharmacist may also be able to help you if you are not sure. If you forget to take your medicine If you do forget to take a dose of your medicine at the correct time, take it as soon as you remember.
Then carry on as before, but do not give two doses within one hour of each other. If you take more capsules than you should If you, or someone you know, accidentally take too much medicine, contact your doctor or pharmacist who will recommend what action you should take, or go to your nearest hospital casualty department.
Remember to take this leaflet and the package with you, to show the doctor what you have taken, whether or not there are any more left. Take the whole course of the medicine that the doctor has prescribed for you. Do not stop taking it just because you feel better. If you stop taking the medicine, your condition may re-occur or get worse. Some patients find that they suffer from an upset stomach or diarrhoea. If you suffer badly from this you should contact your doctor. If you start to suffer from rash, itching or any other skin trouble STOP taking your medicine and tell your doctor.
These may be signs of an allergy to your medicine. If you have any other problems and think that your medicine may be causing them, tell your doctor or pharmacist. Keep it in the pack in which it was given to you. Uses Of Amoxicillin Capsules Amoxicillin Capsules are used to treat infections due to organisms that are susceptible to the effects of amoxicillin. Common infections that amoxicillin is used for include infections of the middle ear, tonsils, throat, larynx laryngitis , bronchi bronchitis , lungs pneumonia , urinary tract, and skin.
It also is used to treat gonorrhea. Amoxicillin Capsules — Dosage The dosage varies as per the indication being treated. For most infections in adults the dosing regimens for Amoxicillin Capsulesare mg every 8 hours, mg every 8 hours, mg every 12 hours or mg every 12 hours, depending on the type and severity of infection.
For the treatment of adults with gonorrhea the dose is 3 g given as one dose. Drug Class and Mechanism Amoxycillin Trihydrate is an antibiotic that belongs to a class of antibiotics called penicillins. These antibiotics all have a similar mechanism of action. They do not kill bacteria, but they stop bacteria from multiplying by preventing bacteria from forming the walls that surround them.
The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together.
Bacteria cannot survive without a cell wall. Amoxicillin Capsules are effective against many different bacteria including H. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
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