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Wash hands with soap often during the day, especially before eating and after using the toilet. Do not scratch the infected area or place your fingers in your mouth. The entire household may need to be treated if one individual in the household has pinworms. Check with your doctor for more information. For several days after treatment with Vermox, clean the bedroom floor by vacuuming or damp mopping.
Avoid dry sweeping because it may stir up dust. Since it is not known if mebendazole is distributed into milk, the drug should be used with caution in nursing women. This interaction is unlikely to be clinically important in patients receiving mebendazole for the management of intestinal helminth infections ; however, use of carbamazepine or phenytoin may prevent an adequate therapeutic response in patients receiving the anthelmintic for the management of extraintestinal infections e.
Pending further accumulation of data, use of alternative anticonvulsant agents e. Acute Toxcicity Overdosage of mebendazole may result in GI symptoms lasting up to a few hours.
If acute overdosage of mebendazole occurs, vomiting and purging should be induced. Activated charcoal may be administered. Mechanism of Action Although the exact mechanism of anthelmintic activity of mebendazole has not been fully elucidated, the drug appears to cause selective and irreversible inhibition of the uptake of glucose and other low molecular weight nutrients in susceptible helminths; inhibition of glucose uptake appears to result in endogenous depletion of glycogen stores in the helminth.
Mebendazole does not inhibit glucose uptake in mammals. Mebendazole appears to cause degenerative changes in the intestine of nematodes and in the absorptive cells of cestodes.
The principal anthelmintic effect of the drug appears to be degeneration of cytoplasmic microtubules within these intestinal and absorptive cells. Microtubular deterioration results in inhibition of organelle movement and interferes with the absorptive and secretory function. As a result of excessive accumulation of intracellular transport secretory granules, hydrolytic and proteolytic enzymes are released and cause cellular autolysis.
This irreversible damage leads to death of the parasite. Mebendazole has no effect on blood glucose concentrations in humans, and examination of the intestine and other organs of treated animals has shown an intact microtubular system and normal subcellular organelles.
The presence of food in the digestive tract of the definitive host does not affect the action of the drug during treatment of intestinal helminthic infections. Mebendazole has been reported to be filaricidal against Mansonella perstans and Onchocerca volvulus. Mebendazole has also been shown to be active against certain cestodes tapeworms , including Hymenolepis nana dwarf tapeworm , Taenia saginata beef tapeworm , T.
Now read the rest of the leaflet before you use this medicine. It includes other information which might be especially important for you. You may need to read it again. Ask your pharmacist if you need any more information or advice. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. What the medicine is for Read indications for use if you want to order Mebendazole online Pripsen Mebendazole Tablets belong to a group of medicines called Anthelmintics which are used to eliminate threadworm infections.
The control Hymenolepis nana in time is approximately 14 days. This is a medicine, no prolonged use without medical advice, keep away from children, read the leaflet carefully. Ask your doctor or pharmacist. In case of side effects, contact your doctor.
In case of existing constipation is necessary to ensure proper relief Yomesan treatment before applying.
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