In most cases peripheral neuropathy disappears when treatment is stopped. Changes to your blood may occur red cells, white cells, platelets, etc.
If there is a tendency to bruise easily, you notice bleeding into the skin, prolonged bleeding, bleeding from the gums or elsewhere, or you feel tired and look pale, stop taking the medicine and see your doctor. Rarely patients may develop liver disease and jaundice yellowing of the skin and the whites of the eyes , or darkening of the urine. If you have any of these effects and they become worse, inconvenient or upsetting; see your doctor or pharmacist.
Patients should be warned that metronidazole may darken urine due to metronidazole metabolite. Patients should be advised not to take alcohol during metronidazole therapy and for at least 48 hours afterwards see section 4. In this population, metronidazole should therefore be used after careful benefit-risk assessment and only if no alternative treatment is available.
Liver function tests must be performed just prior to the start of therapy, throughout and after end of treatment until liver function is within normal ranges, or until the baseline values are reached. If the liver function tests become markedly elevated during treatment, the drug should be discontinued. Patients with Cockayne syndrome should be advised to immediately report any symptoms of potential liver injury to their physician and stop taking metronidazole.
In case of coadministration, prothrombin time should be more frequently monitored and anticoagulant therapy adjusted during treatment with metronidazole. Lithium retention observed by increased plasma lithium levels, accompanied by evidence of possible renal damage has been reported in patients treated simultaneously with lithium and metronidazole.
Plasma levels of lithium may be increased by metronidazole. Lithium treatment should be tapered or withdrawn before administering metronidazole.
Drugs you should not take with metronidazole Disulfiram: Do not take disulfiram with metronidazole. Doing so can cause dangerous effects in your body. Using it with metronidazole can cause psychotic reactions. Interactions that increase your risk of side effects Taking metronidazole with certain medications raises your risk of side effects. This is because the amount of either drug may be increased in your body.
Increased side effects of metronidazole can include a higher risk of QT prolongation irregular heartbeat. Anaerobic Bacteria Metronidazole is active in vitro against most obligate anaerobes but does not appear to possess any clinically relevant activity against facultative anaerobes or obligate aerobes. Against susceptible organisms, metronidazole is generally bactericidal at concentrations equal to or slightly higher than the minimum inhibitory concentrations.
Metronidazole has been shown to have in vitro and clinical activity against the following organisms: Anaerobic gram-negative bacilli, including: Bacteroides species including the Bacteroides fragilis group B. Peptostreptococcus species Susceptibility Tests Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to metronidazole; however, the rapid, routine susceptibility testing of individual isolates of anaerobic bacteria is not always practical, and therapy may be started while awaiting these results.
Quantitative methods give the most precise estimates of susceptibility to antibacterial drugs. A standardized agar dilution method and a broth microdilution method are recommended. Each time the test is performed, one or more of the following strains should be included: The mode metronidazole MICs for those three strains are reported to be 0.
A clinical laboratory is considered under acceptable control if the results of the control strains are within one doubling dilution of the mode MICs reported for metronidazole.
A report of "Resistant" from the laboratory indicates that the infecting organism is not likely to respond to therapy. Asymptomatic Trichomoniasis FLAGYL is indicated in the treatment of asymptomatic females when the organism is associated with endocervicitis, cervicitis, or cervical erosion.
Since there is evidence that presence of the trichomonad can interfere with accurate assessment of abnormal cytological smears, additional smears should be performed after eradication of the parasite. Treatment of Asymptomatic Consorts T. Therefore, asymptomatic sexual partners of treated patients should be treated simultaneously if the organism has been found to be present, in order to prevent reinfection of the partner.
The decision whether to treat an asymptomatic male partner who has a negative culture or one for whom no culture has been attempted is an individual one. In making this decision, it should be noted that there is evidence that a woman may become reinfected if her consort is not treated. Also, since there can be considerable difficulty in isolating the organism from the asymptomatic male carrier, negative smears and cultures cannot be relied upon in this regard.
Amebiasis FLAGYL is indicated in the treatment of acute intestinal amebiasis amebic dysentery and amebic liver abscess. In a mixed aerobic and anaerobic infection, antimicrobials appropriate for the treatment of the aerobic infection should be used in addition to FLAGYL.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of FLAGYL and other antibacterial drugs, FLAGYL should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
WARNINGS Central and Peripheral Nervous System Effects Convulsive seizures, encephalopathy, aseptic meningitis, optic and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, have been reported in patients treated with metronidazole.
Accordingly, for such patients, doses below those usually recommended should be administered cautiously. Known or previously unrecognized candidiasis may present more prominent symptoms during therapy with FLAGYL metronidazole and requires treatment with a candidacidal agent. Prescribing FLAGYL in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.
Patients should be counseled that antibacterial drugs including FLAGYL should only be used to treat bacterial infections.
If possible, go to the toilet and empty your bowels before using your suppository. Flagyl of overdose may include: Use in patients with known hypersensitivity to metronidazole, flagyl tablets 200mg. Take the tablet with you, even if flagyl is empty. This medicine is available only with a doctor's prescription, flagyl tablets 200mg. Taking other medicines Tell your doctor if you 200mg taking any other medicines, including medicines you buy without prescription from a pharmacy, norco 10-325mg street value or health food shop. Ask your doctor if you have any questions about why Flagyl has been prescribed for 200mg. Plasma concentration of lithium, creatinine and electrolytes should be monitored in patients under treatment with lithium while they receive metronidazole. If you take more Flagyl than you should If you take more Flagyl than you should, flagyl tablets 200mg, tell your doctor or go to your nearest hospital casualty department straight away. For these reasons, before you start taking metronidazole it is important that your doctor or dentist knows: Wash your hands thoroughly with soap and water. Do not leave your medicine in the car or on windowsills. The table below contains some of the ones associated with metronidazole. There is no evidence that this medicine is addictive. Store in a cool, dry place, away from direct heat and light.
Pediatric use Safety and effectiveness in pediatric patients have not been established, except for the treatment of amebiasis. Drugs with a possible risk for QT prolongation and TdP that should be 200mg cautiously and with close monitoring with metronidazole include clarithromycin, flagyl tablets 200mg. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with metronidazole include artemether; lumefantrine, flagyl tablets 200mg. Drugs with a possible risk for QT prolongation and torsade de pointes TdP that should be used cautiously and tablet close monitoring with eliglustat include metronidazole including bismuth subcitrate potassium; metronidazole; tetracycline and bismuth subsalicylate; metronidazole; tetracycline. What Flagyl is and what it is used for 2. Your doctor will tell you what dose flagyl right for buy generic loratadine or your childand this will also be printed on the label of the pack to remind you. All medicines have risks and benefits. Things to be careful of Be careful driving or operating machinery until you know how Flagyl affects you. They are packed in a blister and a carton pack contains 10 suppositories.
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