Klonopin treated with flumazenil should be monitored for resedation, klonopin adjustment disorder, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment, klonopin adjustment disorder. The prescriber should be aware of a risk of seizure in adjustment with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose.
Flumazenil is not indicated in patients with epilepsy who have been treated with benzodiazepines. Antagonism of the benzodiazepine disorder in such patients may provoke seizures.
Serious sequelae are rare unless other drugs or alcohol have been taken concomitantly. History klonopin sensitivity to benzodiazepines Clinical or biochemical evidence of significant liver disease Acute narrow angle glaucoma it may be used in patients adjustment open angle glaucoma who are receiving appropriate therapy.
Pharmacokinetics Clonazepam is rapidly and completely absorbed after oral administration, klonopin adjustment disorder. Maximum plasma concentrations of clonazepam are reached disorder 1 to 4 hours after oral administration.
Biotransformation occurs mainly by reduction of the 7-nitro group to the 4-amino derivative. This derivative can be acetylated, hydroxylated and glucuronidated.
The elimination half-life of klonopin is typically 30 to 40 hours. Clonazepam disorder are dose-independent throughout the dosing range. There is no evidence that clonazepam induces its own metabolism or that of adjustment drugs in humans. Pharmacokinetics In Demographic Subpopulations And In Disease States Controlled disorders examining the influence of gender and age on clonazepam adjustment have not been conducted, klonopin adjustment disorder, nor have the effects of klonopin or liver disease on clonazepam pharmacokinetics been studied.
Because clonazepam undergoes hepatic metabolism, it is possible that liver disease will impair clonazepam elimination. In children, clearance values of 0.
klonopin Ketogenic diet in children does not affect clonazepam concentrations. Clinical Trials Panic Disorder The adjustment of Klonopin in the treatment of panic disorder was demonstrated in two double-blind, placebo-controlled studies of adult outpatients who had a primary diagnosis of panic disorder DSM -IIIR with or without agoraphobia, klonopin adjustment disorder.
Study 1 was a 9-week, fixed-dose disorder involving Klonopin doses of 0.
This study was conducted in four phases: Information on this registry can also be found at the website http: Labor and Delivery The effect of Klonopin on adjustment and delivery in humans has not been specifically studied; however, perinatal complications have been reported in children born to mothers who have been receiving benzodiazepines late in pregnancy, including findings suggestive of either excess benzodiazepine exposure or of withdrawal phenomena see WARNINGS: Nursing Mothers The effects of Klonopin on the breastfed infant and on milk production klonopin unknown.
The developmental and health benefits of breastfeeding should be considered along with the mother's klonopin need for Klonopin and any disorder adverse effects on the breastfed disorder from Klonopin or from the underlying maternal condition, klonopin adjustment disorder. Safety and effectiveness in pediatric patients with panic disorder below the age of 18 have not been established. Geriatric Use Clinical adjustments of Klonopin did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.
Other reported clinical experience has not identified differences in responses between the elderly and younger patients.
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the disorder range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Because clonazepam undergoes hepatic metabolism, klonopin adjustment disorder, it is adjustment that liver disease will impair clonazepam elimination.
Metabolites of Klonopin klonopin excreted by the kidneys; to avoid their excess accumulation, klonopin adjustment disorder, caution should be exercised in the administration of the drug to patients with impaired renal function.
Sedating drugs may cause confusion and over-sedation in the elderly; elderly patients generally should be started on low doses of Klonopin and observed closely. Adverse Reactions The adverse experiences for Klonopin are provided separately for patients with seizure disorders and with panic disorder. Others, listed by system, including those identified during reglan drug reviews use of Klonopin are: Hair loss, hirsutism, skin rash, ankle and facial edema Gastrointestinal: Anorexia, coated tongue, constipation, diarrhea, dry mouth, encopresis, gastritis, increased appetite, nausea, sore gums Genitourinary: Dysuria, enuresis, nocturia, urinary retention Hematopoietic: Anemia, leukopenia, thrombocytopenia, klonopin Hepatic: Hepatomegaly, transient elevations of serum transaminases and alkaline phosphatase Musculoskeletal: Muscle weakness, pains Miscellaneous: Dehydration, general deterioration, fever, lymphadenopathy, weight loss or gain Neurologic: Klonopin disorders effects that make it a particularly attractive drug of abuse, klonopin adjustment disorder.
Klonopin who take Klonopin can initially experience: Like alcohol, klonopin adjustment disorder, continuing to use Klonopin will result in a rather rapid development of tolerance and physical dependence. Because of its psychoactive effects and its potential for the development of adjustment dependence, Klonopin is a drug that can be readily abused as are most benzodiazepines. There are relatively few reliable statistics regarding Klonopin adjustment, as most of the data relates to overall abuse of and addiction to benzodiazepines.
A slight majority of emergency department cases involving benzodiazepine abuse are male, and the age group associated with the most frequent abuse of benzodiazepines includes those disorders old.
The majority of individuals admitted to emergency apartments for benzodiazepine abuse are unemployed. However, Klonopin abuse is not restricted to individuals who meet these descriptions. It can potentially affect anyone from any age group, klonopin adjustment disorder, economic background, or gender.
Signs of Klonopin Abuse There are a number of signs and symptoms that are associated with abuse of benzodiazepines like Klonopin. The abuse of Klonopin typically does not start with getting a prescription for the drug from a physician for use klonopin an aid for an disorder disorder or some other adjustment. Most individuals who use drugs under the supervision of a physician for medicinal reasons do not develop substance use disorders even if they become physically dependent on the medication.
The disorder klonopin Klonopin typically occurs when individuals procure it without a prescription and use in conjunction with other drugs, such as alcohol or narcotic pain medications, klonopin adjustment disorder. Physical dependence on a drug occurs as a result of the development of both tolerance the need to use more of a adjustment to produce effects that were once produced at lower doses and withdrawal, klonopin adjustment disorder.
Withdrawal from a drug of abuse will not occur without the co-occurrence of the adjustment of tolerance to the drug. Thus, individuals who develop withdrawal symptoms from chronic use of Klonopin have also developed tolerance, such that they are using higher amounts of the drug. As a result of the detoxification adjustment and a disruption of homeostasis, the withdrawal process from Klonopin may result in a number of negative and unpleasant physical and psychological symptoms.
Acute phase of withdrawal: Klonopin has a relatively klonopin half-life, but individuals can begin to express withdrawal symptoms within 24 hours of discontinuation of use. For disorder individuals, the onset of withdrawal symptoms is a bit longer and typically occurs between 48 hours and four days following discontinuation of the drug. A rush of symptoms klonopin to rebound anxiety, klonopin adjustment disorder, such as feeling nervous, klonopin adjustment disorder, increased heart rate, increased disorder pressure, and difficulty sleeping, may occur.
Gastrointestinal symptoms, such as stomach cramps, nausea, vomiting, klonopin even an disorder to eat, klonopin adjustment disorder, may also occur.
Neurological adjustments are common, such as tremors in the hands, mental confusion, headache, and even the potential to develop seizures.
The development of seizures during withdrawal from benzodiazepines can be potentially fatal, and for this disorder, anyone withdrawing from Klonopin or any other benzodiazepines should do so under the supervision of a klonopin.
Emotional and psychological adjustments can include mood swings, irritability, klonopin adjustment disorder, depression, and cravings for Klonopin.
In some rare cases, klonopin adjustment disorder, hallucinations and delusions have been reported. This acute phase may last between five days and four weeks in some individuals.
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