Zofran odt 8 mg used
There is no experience beyond first-day administration of ondansetron [see Clinical Pharmacology Drug Abuse and Dependence Animal studies have shown that ondansetron is not discriminated odt a benzodiazepine nor does it substitute for benzodiazepines in used addiction studies.
Overdosage There is no zofran antidote for ondansetron overdose. Patients should be managed with appropriate supportive therapy. In addition to the adverse reactions listed above, the following adverse reactions have been described in the setting of ondansetron overdose: Hypotension and faintness occurred in a patient that took 48 mg of ondansetron tablets, zofran odt 8 mg used.
ondansetron (oral) (Zofran, Zofran ODT, Zuplenz)
Following infusion of 32 mg used only a 4-minute period, a vasovagal episode with transient second-degree heart block was observed.
In all instances, the adverse reactions resolved completely. Pediatric cases consistent with serotonin syndrome have been reported after inadvertent oral overdoses of ondansetron exceeding estimated ingestion of 5 mg per kg in zofran children. Reported symptoms included somnolence, agitation, tachycardia, tachypnea, hypertension, flushing, mydriasis, odt, myoclonic movements, horizontal nystagmus, hyperreflexia, and seizure. Patients required supportive care, including intubation in some cases, with complete recovery without sequelae within 1 to 2 days.
Ondansetron ODT Description The active ingredient in ondansetron orally disintegrating tablets, USP is ondansetron base, the racemic form of ondansetron and a selective blocking agent of the serotonin 5-HT3 receptor type.
ONDANSETRON 8 MG TABLETS
It has the following structural formula: The molecular formula is Odt representing a molecular weight of Ondansetron is a white to off-white powder. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Ondansetron can be taken with or without food. Take the ondansetron regular tablet with a full glass of water. To take ondansetron orally disintegrating tablet Zofran ODT: Keep the tablet in its blister pack until zofran are used to take the medicine, zofran odt 8 mg used.
Ondansetron
Open the package and peel back the foil from the tablet blister. Taking this drug with ondansetron can cause your blood pressure to drop to unsafe levels.
This can cause you to pass out, zofran odt 8 mg used. Interactions that increase your risk of side effects from ondansetron Taking ondansetron with used medications raises zofran risk of side effects from ondansetron.
This is because the amount odt ondansetron in your body may be increased.
Other drugs that affect serotonin levels, such as fluoxetine and paroxetine. Interactions that can zofran ondansetron less effective Taking these drugs with ondansetron can make ondansetron less effective. This is because the amount of ondansetron in your body may odt decreased, zofran odt 8 mg used.
Anti-seizure drugs, such as phenytoin or carbamazepine. Multiday administration of ondansetron has been shown to slow colonic transit in healthy subjects. Ondansetron has no effect on plasmaprolactin concentrations. Cardiac Electrophysiology QTc interval prolongation was studied in a double-blind, single-intravenous dose, placebo-and positive-controlled, used trial in 58 healthy subjects.
In this study, the 8-mg dose infused over 15 minutes did not prolong the QT interval to any clinically relevant extent, zofran odt 8 mg used. Pharmacokinetics Absorption Ondansetron is absorbed from the gastrointestinal tract and undergoes some first-pass metabolism.
Ondansetron systemic exposure does not increase proportionately to dose.
This may reflect some reduction of first-pass metabolism at higher oral doses, zofran odt 8 mg used. Food Effects Bioavailability is zofran slightly enhanced by the presence of food. Circulating drug also distributes into erythrocytes.
The metabolites are observed in the urine. The primary metabolic pathway is hydroxylation on the indole odt followed by subsequent glucuronide or sulfate conjugation. In terms of used ondansetron turnover, CYP3A4 played the predominant role.
Because of the multiplicity of metabolic enzymes capable of metabolizing ondansetron, zofran odt 8 mg used, it is likely that inhibition or loss of one enzyme e. This is because safety of ondansetron for use in human pregnancy has not been established. Do not take Ondansetron Tablet if you are breast-feeding, because it is excreted into the milk. Driving and using machines Ondansetron may cause problems with your vision.
If affected do not drive or operate machinery. Psychomotor testing testing of brain and body coordination does not impair performance nor cause sedation.
A study of usedpregnancies in Denmark found that ondansetron zofran pregnancy was not associated with a significantly increased risk of spontaneous abortionstillbirthmajor birth defectodt birthlow birth weightor small for gestational age.
11335 EN Ondansetron ODT 8 mg tid q8h prn
Its use reduced hospital admissions, but was also associated with higher rates of return visits to the emergency department. Furthermore, people who had used received ondansetron were more likely to be admitted on the return visit than people who had not received the drug, zofran odt 8 mg used.
However, this effect zofran simply be due to odt agent being used more frequently in people who present with more severe illness.