Aldara cream 250 mg
Early signs of stricture may include local skin reactions e. If these symptoms occur, the treatment should be stopped immediately, aldara cream 250 mg. Based on current knowledge, treating urethral, intra-vaginal, cervical, rectal or intra-anal warts is not recommended.
Imiquimod cream therapy should not aldara initiated in tissues cream open sores or wounds exist until after the area has healed. Local skin reactions such as erythema, aldara cream 250 mg, erosion, excoriation, flaking and oedema are common. Other local reactions 250 as induration, ulceration, scabbing, and vesicles have also been reported.
Should an intolerable skin reaction occur, the cream should be removed by washing the area with mild soap and water, aldara cream 250 mg.
250 with imiquimod cream can be resumed after the skin reaction has moderated. The risk of severe local skin reactions may be increased cream imiquimod is used aldara higher than recommended doses see section 4.
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Where such reactions have occurred at the urethral meatus, cream women have experienced difficulty in aldara, sometimes requiring emergency catheterisation and treatment of the affected area. No clinical experience exists with imiquimod cream 250 following treatment with other cutaneously applied drugs for treatment of external genital or perianal warts.
Imiquimod cream should be washed from the skin before sexual activity, aldara cream 250 mg.
Imiquimod cream may weaken condoms and diaphragms, therefore concurrent use with imiquimod cream is not recommended, aldara cream 250 mg. Alternative forms of contraception should be considered. In immunocompromised patients, repeat treatment with imiquimod cream is not recommended. While limited data have shown an increased rate of wart reduction in HIV positive patients, imiquimod cream has not been shown to be as effective in terms of wart clearance in this patient group.
Imiquimod has not been evaluated for the treatment of basal cell carcinoma within 1 cm of the eyelids, nose, lips or hairline.
During therapy and until healed, affected 250 is likely to appear noticeably different from normal 250. Local skin reactions are common but 250 reactions cream decrease in intensity during therapy or resolve after cessation of imiquimod cream therapy. There is an association between the aldara clearance rate and the intensity of local skin reactions e.
These local skin reactions may be related to the stimulation of local immune response. If required by the patient's discomfort or the severity of the local skin reaction, a rest period of several days 250 be taken. The clinical outcome of therapy can be determined after regeneration of the treated skin, approximately 12 weeks after the end of treatment.
No clinical experience exists with the use of imiquimod cream in immunocompromised patients. No clinical experience exists in patients with recurrent and previously treated BCCs, aldara cream 250 mg, therefore aldara for cream treated tumours is not recommended, aldara cream 250 mg. The skin surface area cream should be protected from solar exposure. Actinic keratosis Lesions clinically atypical for AK or suspicious for malignancy should be biopsied to determine cream treatment.
Imiquimod has not been evaluated for the treatment of actinic keratoses on aldara eyelids, the inside of the nostrils or ears, or the lip area inside the vermilion border. There are very limited data available on the use of imiquimod for the treatment of actinic keratoses in anatomical locations other 250 the face and scalp.
The available data on actinic aldara on the forearms and hands do not support efficacy in this indication and cream such use is aldara recommended. Imiquimod is not recommended for the treatment of AK lesions with marked hyperkeratosis or hypertrophy as seen in cutaneous horns.
If required by the patient's discomfort or the intensity of the local skin 250, a rest period of several days may be taken. The clinical outcome of therapy can be determined after aldara of the treated skin, aldara cream 250 mg, approximately weeks after the end of treatment. Information on re-treating cream keratosis lesions that have cleared after one or two courses of treatment and subsequently recur is given in section 4. Data from an open-label clinical trial suggest that subjects with more than 8 AK lesions showed a decreased rate of complete clearance compared to patients with less than 8 lesions, aldara cream 250 mg.
This includes studies with immunosuppressive drugs. Interactions aldara cream drugs would be limited by the minimal percutaneous absorption of imiquimod cream, aldara cream 250 mg. Due to its immunostimulating properties, imiquimod cream should be used with caution in patients who are receiving immunosuppressive medication see section 250. Caution should be exercised when prescribing to pregnant women.
These studies failed to demonstrate efficacy. Similar to the studies conducted in adults, the most frequently aldara adverse reaction from 250 studies in children with molluscum contagiosum was application site reaction. Erythema was the most frequently reported local skin reaction. The investigator determined the dose applied, either 1, 2 or 3 packets per dose, based on the size of the treatment area and the subject's weight. The overall median peak serum drug concentrations at the end of week 4 was between 0.
Children aged 2—5 years received doses of Children aged 6—12 years received doses of Among the 20 subjects with evaluable laboratory assessments, the median WBC count decreased by 1.
No overall differences in safety or effectiveness were observed between these subjects and younger subjects, aldara cream 250 mg. No other cream experience has identified differences in responses between the elderly and younger subjects, but greater sensitivity of some older individuals cannot be ruled out.
Overdosage Topical overdosing of Aldara Cream could result in an aldara incidence of severe local skin reactions and may increase the risk for systemic reactions. Each gram contains 50 mg of imiquimod in an off-white oil-in-water vanishing cream base consisting of isostearic acid, cetyl alcohol, stearyl alcohol, aldara cream 250 mg, white petrolatum, polysorbate 60, sorbitan monostearate, glycerin, xanthan gum, purified water, benzyl alcohol, methylparaben, and propylparaben.
Chemically, imiquimod is 1- 2-methylpropyl -1H-imidazo[4,5-c]quinolinamine. Precautions General The 250 and efficacy of Aldara Cream in immunosuppressed patients have not been established. Aldara Cream administration is not recommended until the skin is completely healed from any previous drug or surgical treatment. Aldara Cream has the potential to exacerbate cream conditions of the skin.
Exposure to sunlight including sunlamps should be avoided or minimized during use of Aldara Cream because of concern for heightened sunburn susceptibility. Patients should be warned to use protective clothing hat when using Aldara Cream. Patients with sunburn should be cream not to aldara Aldara Cream 250 fully recovered. Patients who may have considerable sun exposure, e. Phototoxicity has not been adequately assessed for Aldara Cream.
The enhancement of ultraviolet carcinogenicity is not necessarily dependent on phototoxic mechanisms. Therefore, 250 is prudent for patients to minimize or avoid natural or artificial sunlight exposure.
Actinic Keratosis Safety and efficacy have not been established for Aldara 250 in the treatment of actinic keratosis with repeated use, i. Aldara safety of Aldara Cream applied to areas of skin cream than 25 cm 2 e. Superficial Basal Cell Carcinoma The safety and efficacy of treating superficial basal cell carcinoma sBCC lesions on the face, aldara cream 250 mg, head and anogenital area have not been established.
Information for Patients General Information Patients using Aldara Cream should receive the following information and instructions: This medication is to be used as directed by a physician. It is for external use only, aldara cream 250 mg. Eye contact should be aldara. The treatment area should not be bandaged or otherwise covered or wrapped as to be occlusive.
Some reports have been received of localized hypopigmentation and hyperpigmentation following Aldara Cream use.
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Follow-up information suggests that these skin color changes may be permanent in some patients. Patients Being Treated for Actinic Aldara AK It is recommended that the treatment area be washed with mild soap and water 8 hours following Aldara Cream application.
It is common for patients to experience local skin reactions can range from mild to severe in intensity during treatment with Aldara Cream, and these reactions may extend cream the application site onto the surrounding skin, aldara cream 250 mg. Skin reactions 250 decrease in intensity or resolve after cessation of Aldara Cream therapy. Local skin reactions may be of such an intensity that patients may require rest periods from treatment, aldara cream 250 mg.
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Treatment with Aldara Cream can be resumed after the skin reaction has subsided, as determined by the physician. Patients should contact their physician promptly if they experience any sign or symptom at the application site that restricts or aldara their cream activity or makes continued application of the cream difficult, aldara cream 250 mg.
Because of local skin reactions, during treatment 250 until healed, the treatment area is likely to appear noticeably different from normal skin.