Contra-indicated in patients hypersensitive to isosorbide dinitrate.
ISORDIL should not be used in patients with severe anaemia, recent head trauma or cerebral haemorrhage, ismo renal or hepatic impairment, or in patients with increased intracranial pressure. Safety in pregnancy and 5mg has not been established.
Safety and effectiveness in paediatric patients have not been establised. Tolerance may develop with daily use but gradual withdrawal restores the original sensitivity. Although the overall incidence of Tartrazine sensitivity ismo the general population is currently thought to be low, ismo 5mg, it is frequently seen in patients who also have aspirin 5mg.
Amplification 5mg the vasodilatory effects of Isordil by sildenafil ismo result in severe hypotension. The sublingual tablets may also 5mg taken orally in patients requiring dosage adjustment because of headache during ismo early stages of therapy, ismo 5mg.
Increases in dosage should be gradual to avoid side-effects. They are indicated for sustained prophylaxis against angina pectoris attacks including nocturnal angina. Although the latter condition is relatively infrequent, it is nonetheless angina, i, ismo 5mg. Although experiencing ismo reduction in the number of anginal attacks while under TEMBIDS therapy, patients may still have 5mg attack under stressful conditions.
Ismo onset of action of oral isosorbide mononitrate is not sufficiently rapid for this product to be useful in 5mg an acute anginal episode. Contraindications Allergic reactions to organic nitrates are extremely rare, ismo 5mg, but they do occur.
Isosorbide mononitrate is contraindicated in patients who are allergic to it, ismo 5mg. Warnings Amplification of the vasodilatory effects of Ismo by sildenafil can result in severe hypotension.
The time course and dose dependence of this interaction have not been studied, ismo 5mg. Appropriate supportive care has not been studied, but it seems reasonable 5mg treat this as a nitrate overdose, with elevation ismo the extremities and with central volume expansion.
The benefits of isosorbide mononitrate in patients with acute myocardial infarction or congestive heart failure have not been 5mg. Because the effects of isosorbide mononitrate are difficult to terminate rapidly, ismo 5mg, this drug is not 5mg in these ismo. If isosorbide mononitrate is used in these conditions, careful clinical or hemo-dynamic monitoring must be used to ismo the hazards of hypotension and tachycardia.
Precautions General Severe hypotension, particularly with upright posture, may occur with even small doses of isosorbide mononitrate. 5mg drug should therefore be used with caution in patients who may be volume depleted or who, for whatever reason, are already hypotensive.
Hypotension induced by isosorbide mononitrate may be accompanied by paradoxical bradycardia and increased angina pectoris. Nitrate therapy may aggravate the angina caused by hypertrophic cardiomyopathy. In industrial workers who have had long-term exposure to unknown presumably high doses of organic ismo, tolerance clearly occurs. Side effect or health problem is not better or you are feeling worse.
Ismo I 5mg Isosorbide Mononitrate with other medicines: Sometimes drugs are not safe when you take them with certain other drugs and food.
Store in a 5mg, dry place away from the reach of children. Pregnancy Category Category C: Animal reproduction studies have shown an adverse effect on the 5mg and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant 5mg despite potential risks. Carcinogenesis, Mutagenesis, Impairment of Fertility: No mutagenic activity zarator 10mg atorvastatin seen in a variety of in vitro ismo in vivo assays, ismo 5mg.
There are no adequate and well-controlled studies in pregnant women. Isosorbide mononitrate should be used during pregnancy only if the potential ismo justifies the potential risk to the ismo.
It is not known whether ismo mononitrate is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when isosorbide mononitrate is administered to a nursing woman. Because many drugs are excreted in human milk, caution should 5mg exercised when isosorbide mononitrate is administered to a nursing woman.
Pediatric Use Safety and effectiveness of isosorbide mononitrate in pediatric patients have not been ismo. Geriatric Use Clinical studies of Ismo isosorbide mononitrate did not include sufficient numbers of subjects aged 65 and over to determine whether 5mg respond differently from younger subjects, ismo 5mg. Other reported clinical experience ismo not identified differences in responses between the elderly and younger patients.
These hemodynamic changes may have protean manifestations, including increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever ; vertigo ; palpitations ; visual disturbances; nausea and vomiting possibly with 5mg and even bloody diarrhea ; syncope especially in the upright posture ; air hunger and dyspnealater followed by reduced ventilatory effort; diaphoresis, ismo the skin ismo flushed or cold and clammy; heart block and bradycardia ; paralysis ; coma ; seizures and death, ismo 5mg, ismo 5mg.
Laboratory determinations of serum levels of isosorbide mononitrate and its 5mg are not widely available, ismo 5mg, and such determinations have, in any event, no established role in the management of isosorbide mononitrate overdose.
There are no data suggesting what dose of isosorbide mononitrate is likely to be life-threatening in humans. No data are available to suggest 5mg maneuvers e, ismo 5mg.
In particular, ismo 5mg, dialysis is known to be ineffective in removing isosorbide mononitrate from the body. No specific antagonist to the vasodilator effects of isosorbide mononitrate is known, and no intervention has been subject to controlled study as ismo therapy of isosorbide mononitrate overdose. 5mg the hypotension associated with isosorbide mononitrate overdose is the result of venodilatation and arterial hypovolemiaprudent therapy in this situation should be directed toward an increase in central fluid volume.
Passive elevation of the patient's legs may be sufficient, ismo 5mg, but intravenous infusion of normal saline or similar fluid may also be necessary. The use of epinephrine or other arterial vasoconstrictors in this setting is likely to do more harm than good. In patients with renal disease or congestive heart failuretherapy resulting in central volume expansion is not without hazard.
Treatment of isosorbide mononitrate overdose in these patients ismo be subtle and difficult, and invasive monitoring may be 5mg. Methemoglobinemia Methemoglobinemia has been reported in patients receiving other organic nitrates, and it probably could also occur as a side effect of isosorbide mononitrate.
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