Detrol tab 2mg

In the presence of ketoconazole, the mean Cmax and AUC of tolterodine increased by 2 and 2. Based on these findings, other potent CYP3A inhibitors such as other azole antifungals 2mg. Warfarin In healthy volunteers, coadministration of tolterodine immediate release 4 mg 2 mg bid for 7 days and a single dose of warfarin 25 mg on day 4 had no effect on prothrombin time, Factor VII suppression, or on the pharmacokinetics of warfarin.

Diuretics Coadministration of tolterodine immediate release up to 8 mg 4 mg bid for up to 12 weeks with diuretic agents, such as indapamide, hydrochlorothiazide, triamterene, bendroflumethiazide, chlorothiazide, methylchlorothiazide, or furosemide, did not cause tab adverse electrocardiographic ECG effects. QT interval was measured over a hour period following dosing, including the time of detrol plasma concentration Tmax of tolterodine and at steady state Day 4 of dosing.

Table 2 summarizes the tab change from baseline to steady state in corrected QT interval QTc relative 2mg placebo at the time of peak tolterodine 1 hour and moxifloxacin 2 hour concentrations. Use in children Tolterodine tablets is not recommended for children, detrol tab 2mg. Duration of treatment Your doctor will tell you how long your treatment with Tolterodine tablets will last. Do not stop treatment early because you do not see an immediate effect. Your bladder will need some time to adapt.

Finish the course of tablets prescribed by your doctor, detrol tab 2mg. If you have not noticed any effect by then, talk to your doctor. The benefit of the treatment should be re-evaluated after 2 or 3 months. If you take more Tolterodine tablets detrol you should If you or somebody else takes too many tablets, contact your doctor, accident and emergency department or pharmacy at once.

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If you tab to detrol Tolterodine tablets Do not take a double dose to make up for a forgotten one. If you have forgotten to take a dose at the usual time, you can take it as soon as you remember detrol it is almost time 2mg your next dose. In that case you should not take the forgotten dose but follow the normal dose schedule. If you stop taking Tolterodine tablets Always consult your doctor if you are thinking of stopping the treatment, detrol tab 2mg, detrol tab 2mg.

If you tab any further questions on the 2mg of this medicine, ask your doctor or pharmacist.

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The results Fridericia corrected at peak tolterodine concentration 1 hour showed mean QTc interval increases of 5. At both doses of tolterodine, no subject, irrespective of their metabolic profile, exceeded msec for absolute QTcF or 60 msec for change from baseline that are considered thresholds of particular concern. The 4 mg BID dose corresponds to a peak exposure Cmax of three times that obtained with the highest therapeutic dose of Protol SR capsules, detrol tab 2mg.

Paediatric population Efficacy in the paediatric population has not been demonstrated. Two paediatric phase 3 randomised, placebo-controlled, double-blind 12 week studies were conducted using tolterodine extended release capsules.

A total of paediatric patients on tolterodine and on placebo aged years with urinary frequency and urge urinary incontinence were studied.

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Tolterodine is rapidly absorbed. Both tolterodine and the 5-hydroxymethyl metabolite reach maximal serum concentrations hours after dose. The half-life for tolterodine given as the tablet is hours in extensive and about 10 hours in poor metabolisers devoid of CYP2D6. Steady 2mg concentrations are reached within 2 days after administration of the tablets, detrol tab 2mg. Patients should be advised to exercise caution in detrol to engage in potentially dangerous activities tab the drug's effects have been determined.

For patients receiving ketoconazole or other potent CYP3A4 inhibitors such as other azole antifungals e. Tab Interactions Interactions between tolterodine and laboratory tests have not been studied. Carcinogenesis, Mutagenesis, Impairment of Fertility Carcinogenicity studies 2mg tolterodine were conducted in mice and rats.

Thus, tolterodine exposure in detrol carcinogenicity studies was 9- to fold higher than expected in humans, detrol tab 2mg.

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No increase in tumors was found in either mice or rats, detrol tab 2mg. No mutagenic effects of tolterodine were detected in a battery of in vitro tests, including bacterial mutation assays Ames test in 4 strains of Salmonella typhimurium and in 2 strains of Escherichia coli, a gene mutation assay in LY mouse lymphoma cells, and chromosomal aberration tests in human lymphocytes.

Tolterodine was also negative in vivo in the bone marrow micronucleus test in the mouse.