Take one tablet at a time. Also, do not give this medicine through nasogastric or feeding tubes. If you are using the extended release capsules: Take this medicine with food and with approximately the same amount of food each time. If you have trouble swallowing, you may open the capsule and sprinkle the contents on soft foods eg, applesauce, pudding, ice cream, or jam or into a cup and then give it directly into the mouth and swallow immediately.
Drink a glass of water to make sure all medicine has been taken. This medicine may also be given through a feeding tube. Oxycodone extended-release capsules or tablets work differently from the regular oxycodone oral solution or tablets, even at the same dose. Do not switch from one brand or form to the other unless your doctor tells you to.
Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine.
If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form extended-release capsules: If opioid treatment is considered appropriate for the patient, then the main aim of treatment is not to minimise the dose of opioid but rather to achieve a dose, which provides adequate pain relief with a minimum of side effects.
There must be frequent contact between physician and patient so that dosage adjustments can be made. It is strongly recommended that the physician defines treatment outcomes in accordance with pain management guidelines. The physician and patient can then agree to discontinue treatment if these objectives are not met. The patient may develop tolerance to the drug with chronic use and require progressively higher doses to maintain pain control. Prolonged use of this product may lead to physical dependence and a withdrawal syndrome may occur upon abrupt cessation of therapy.
When a patient no longer requires therapy with oxycodone, it may be advisable to taper the dose gradually to prevent symptoms of withdrawal. The opioid abstinence or withdrawal syndrome is characterised by some or all of the following: Other symptoms also may develop, including: Hyperalgesia that will not respond to a further dose increase of oxycodone may occur, particularly in high doses.
An oxycodone dose reduction or change to an alternative opioid may be required. Oxycodone has an abuse profile similar to other strong opioids. Oxycodone may be sought and abused by people with latent or manifest addiction disorders. There is potential for development of psychological dependence [addiction] to opioid analgesics, including oxycodone. OxyContin should be used with particular care in patients with a history of alcohol and drug abuse. As with other opioids, infants who are born to dependent mothers may exhibit withdrawal symptoms and may have respiratory depression at birth.
OxyContin tablets must be swallowed whole, and not broken, chewed or crushed. The administration of broken, chewed, or crushed OxyContin tablets leads to a rapid release and absorption of a potentially fatal dose of oxycodone see Section 4.
Concomitant use of alcohol and OxyContin may increase the undesirable effects of OxyContin; concomitant use should be avoided. Abuse of oral dosage forms by parenteral administration can be expected to result in serious adverse events, such as local tissue necrosis, infection, pulmonary granulomas, increased risk of endocarditis, and valvular heart injury, which may be fatal.
Empty matrix tablets may be seen in the stools. Concomitant administration of oxycodone with anticholinergics or medicines with anticholinergic activity e. Oxycodone should be used with caution and the dosage may need to be reduced in patients using these medications. MAO inhibitors are known to interact with narcotic analgesics.
MAO inhibitors cause CNS excitation or depression associated with hypertensive or hypotensive crisis see section 4. Alcohol may enhance the pharmacodynamic effects of OxyContin; concomitant use should be avoided. Physical dependence on a prescribed medication does not signify addiction.
Physical dependence involves the occurrence of a withdrawal syndrome when there is sudden reduction or cessation in drug use or if an opiate antagonist is administered. Physical dependence can be detected after a few days of opioid therapy. However, clinically significant physical dependence is only seen after several weeks of relatively high dosage therapy. In this case, abrupt discontinuation of the opioid may result in a withdrawal syndrome. If the discontinuation of opioids is therapeutically indicated, gradual tapering of the drug over a 2-week period will prevent withdrawal symptoms.
Too much acetaminophen can damage the liver and cause death. While taking oxycodone with acetaminophen, do not take nonprescription acetaminophen or other medicines that contain acetaminophen, including many cold medicines. Adults should not take more than 3, to 4, mg of acetaminophen each day. Depending on what your doctor prescribed, each tablet or liquid dose of this medicine contains between mg and mg of acetaminophen.
Let your doctor and pharmacist know about all the prescription and nonprescription medicines you are taking, so other medicines that contain acetaminophen can be identified. Always read the active ingredients on medicine labels under Drug Facts on nonprescription medicine labels to avoid taking other medicines that contain acetaminophen. You may feel sleepy while taking this medicine. Avoid tasks that require mental alertness, such as driving or operating machinery.
Avoid drinking alcohol while taking this medicine. Prevent and treat constipation.
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