Qualitative and quantitative composition 5 mg tablet contains 4. For the full list of excipients, see Section 6. Pharmaceutical form Prolonged release round, convex tablet. The 5 mg tablets are light blue, marked OC on one side and 5 on the other. The 10 mg tablets are white, marked OC on one side and 10 on the other. The 15 mg tablets are grey, marked OC on one side and 15 on the other.
The 20 mg tablets are pink, marked OC on one side and 20 on the other. The 30 mg tablets are brown, marked OC on one side and 30 on the other.
The 40 mg tablets are yellow, marked OC on one side and 40 on the other. The 60 mg tablets are red, marked OC on one side and 60 on the other. The 80 mg tablets are green, marked OC on one side and 80 on the other. The mg tablets are purple, marked OC on one side and on the other. For the treatment of severe pain requiring the use of a strong opioid.
OxyContin tablets should be taken at hourly intervals. The dosage is dependent on the severity of the pain, and the patient's previous history of analgesic requirements.
OxyContin is not intended for use as a prn analgesic. Increasing severity of pain will require an increased dosage of OxyContin tablets, using the 5 mg, 10 mg, 20 mg, 40 mg or 80 mg tablet strengths, either alone or in combination, to achieve pain relief. The correct dosage for any individual patient is that which controls the pain and is well tolerated for a full 12 hours. Patients should be titrated to pain relief unless unmanageable adverse drug reactions prevent this.
The need for escape medication more than twice a day indicates that the dosage of OxyContin tablets should be increased. Some patients may benefit from a starting dose of 5 mg to minimise the incidence of side effects. The dose should then be carefully titrated, as frequently as once a day if necessary, to achieve pain relief.
For the majority of patients, the maximum dose is mg hourly. However, a few patients may require higher doses. Doses in excess of mg daily have been recorded. Conversion from oral morphine: Other provinces have proposed similar legislation, while some, such as Nova Scotia, have legislation already in effect for monitoring prescription drug use. This was a first for any province to delist a drug based on addictive properties.
The new law prohibits prescriptions for OxyNeo except to certain patients under the Exceptional Access Program including palliative care and in other extenuating circumstances. Patients already prescribed oxycodone will receive coverage for an additional year for OxyNeo, and after that, it will be disallowed unless designated under the exceptional access program.
The new formulation, OxyNeo, is intended to be preventative in this regard and retain its effectiveness as a painkiller. Since introducing its Narcotics Safety and Awareness Act, Ontario has committed to focusing on drug addiction, particularly in the monitoring and identification of problem opioid prescriptions, as well as the education of patients, doctors, and pharmacists.
Because laws are largely provincially regulated, many speculate a national strategy is needed to prevent smuggling across provincial borders from jurisdictions with looser restrictions. In June , then federal Minister of Health Rona Ambrose announced that within three years all oxycodone products sold in Canada would need to be tamper-resistant. During the long-term phase of the study, the dosage of CR oxycodone became constant at approximately 40 mg per day by week 16, while analgesia was maintained.
A higher percentage of patients required downward titration as the trial progressed. Pain was controlled below a "moderate" level throughout the long-term trial with no significant trends from week 2 to the end of the trial. Withdrawal syndrome was not reported as an adverse event during scheduled respites, indicating that CR oxycodone at dosages less than 60 mg per day can be discontinued without tapering the dosage, if necessary.
The use of CR oxycodone did not lead to a deterioration or an improvement in daily activities over the long course of therapy. The authors conclude that patients with moderate to severe pain from osteoarthritis can achieve effective pain relief without deterioration in function when opioids are included as part of a comprehensive pain management program.
One of the significant results from this study was the finding that patients treated with sustained dosages of opioids were not impaired during their daily activities. In addition to the reduction in daily pain intensity, the patients were able to obtain better sleep with fewer night awakenings. Therefore, dose initiation should follow a conservative approach.
Children under 18 years: Oxycodone solution should not be used in patients under 18 years. Use in non-malignant pain: Opioids are not first line therapy for chronic non-malignant pain, nor are they recommended as the only treatment.
Types of chronic pain which have been shown to be alleviated by strong opioids include chronic osteoarthritic pain and intervertebral disc disease. The need for continued treatment in non-malignant pain should be assessed at regular intervals. When a patient no longer requires therapy with oxycodone, it may be advisable to taper the dose gradually to prevent symptoms of withdrawal.
Oxycodone must not be used in any situation where opioids are contraindicated: Caution must be exercised when administering oxycodone to the debilitated elderly; opioid-dependent patients; patients with severely impaired pulmonary function, patients with impaired hepatic or renal function; patients with myxedema, hypothyroidism, Addison's disease, toxic psychosis, prostate hypertrophy, adrenocortical insufficiency, alcoholism, delirium tremens, diseases of the biliary tract, pancreatitis, inflammatory bowel disorders, hypotension, hypovolaemia, raised intracranial pressure, head injury due to risk of increased intracranial pressure or patients taking MAO inhibitors.
Oxycodone solution should not be used where there is a possibility of paralytic ileus occurring. Should paralytic ileus be suspected or occur during use, Oxycodone solution should be discontinued immediately.
Oxycodone solution should be used with caution pre-operatively and within the first 24 hours post-operatively. As with all opioid preparations, oxycodone products should be used with caution following abdominal surgery as opioids are known to impair intestinal motility and should not be used until the physician is assured of normal bowel function.
Patients about to undergo additional pain relieving procedures e. If further treatment with oxycodone is indicated then the dosage should be adjusted to the new post-operative requirement. For appropriate patients who suffer with chronic non-malignant pain, opioids should be used as part of a comprehensive treatment programme involving other medications and treatment modalities.
A crucial part of the assessment of a patient with chronic non-malignant pain is the patient's addiction and substance abuse history. If opioid treatment is considered appropriate for the patient, then the main aim of treatment is not to minimise the dose of opioid but rather to achieve a dose which provides adequate pain relief with a minimum of side effects. There must be frequent contact between physician and patient so that dosage adjustments can be made.
It is strongly recommended that the physician defines treatment outcomes in accordance with pain management guidelines.
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© Copyright 2017 Oxycontin 160mg discontinued *** It is available in tablets of 10, 15, 20, 30, 40, 60, and 80 mg (the mg tablet has been discontinued). Oxycodone, What is Oxycontin and morphine mixed?.