The dose of omeprazole is only disclosed in the fine print. Omeprazole is a proton pump inhibitor that has been used for years to treat peptic ulcers and gastro-oesophageal reflux disease by reducing gastric acid levels. Omeprazole 20mg contains about 10mg of S-omeprazole and 10mg of its mirror molecule: Both S and R-omeprazole are converted to the same active drug that reduces production of gastric acid by proton pumps.
R-omeprazole is absorbed into the body less than S-omeprazole and removed faster, so it may be less effective than S-omeprazole. Esomeprazole is just a different spelling for S-omeprazole. AstraZeneca are using a different spelling that makes it less obvious that esomeprazole is just half of their old drug omeprazole Losec. It is no surprise that 40mg S-omeprazole in Nexium 40mg is more effective than the 10mg of S-omeprazole plus 10mg of R-omeprazole. The other comparison is esomeprazole Nexium 40mg vs lansoprazole Zoton 30mg.
But, it has a greater bioavailability than omeprazole. This is a drug that has some effects on several enzymes causing increases in the doses of warfarin and diazepam, and reduced function of clopidogrel. The adverse effects of this drug include the above mentioned adverse effects of omeprazole, as well as loss of appetite, constipation and dry mouth with more sever effects such as allergic reactions, dark urine, paresthesia, severe abdominal pain, etc.
What is the difference between Omeprazole and Esomeprazole? The similarities between these two drugs outweigh the dissimalirities. Both of them are proton pump inhibitors, with similar mechanisms of action, similar actions done on the drug by the body, with similar drug interactions, and similar spread of adverse effects. The main dissimilarity between the two comes from the chemical composition, the greater biovailability of esomeprazole over omeprazole, and the extended array of possible side effects due to esomeprazole.
If the acid is produced in excess and refluxes into the esophagus, it causes heartburn. Proton pump inhibitors turn off pumps in the stomach to reduce acid production to an amount just enough for digestion. While Antacids and H2 blockers provide temporary relief for a few hours, proton pump inhibitors like Nexium and Prilosec can provide relief for a longer duration. This video explains how PPIs work: Esomeprazole is used primarily for gastroesophageal reflux disease, treatment and maintenance of erosive esophagitis, treatment of duodenal ulcers caused by H.
Omeprazole is used to treat gastroesophageal reflux disease, gastric and duodenal ulceration, and gastritis. People with allergies to Esmeprazole should avoid Nexium, and those with allergies to Omeprazole should not take Prilosec. Treatment Nexium and Prilosec are used to reduce the acid in the stomach that causes frequent heartburn and conditions associated with it.
Nexium is mainly used as a treatment for GERD Gastro esophageal reflux disease and Zollinger-Ellison Syndrome, which produces tumors that secrete excess stomach acid.
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