When Indomethacin is given to patients receiving probenecid, the plasma levels of Indomethacin are likely to be increased. During the concomitant use of Indomethacin capsules and probenecid, a lower total daily dosage of Indomethacin may produce a satisfactory therapeutic effect. When increases in the dose of Indomethacin are made, they should be made carefully and in small increments.
Effects on Laboratory Tests Indomethacin capsules reduce basal plasma renin activity PRA , as well as those elevations of PRA induced by furosemide administration, or salt or volume depletion. These facts should be considered when evaluating plasma renin activity in hypertensive patients. False-negative results in the dexamethasone suppression test DST in patients being treated with Indomethacin have been reported.
Thus, results of the DST should be interpreted with caution in these patients. Avoid use of NSAIDs, including Indomethacin capsules, in pregnant women starting at 30 weeks of gestation third trimester.
There are no adequate and well-controlled studies of Indomethacin capsules in pregnant women. Data from observational studies regarding potential embryofetal risks of NSAID use in women in the first or second trimesters of pregnancy are inconclusive.
In the general U. In animal reproduction studies, retarded fetal ossification was observed with administration of Indomethacin to mice and rats during organogenesis at doses 0. In published studies in pregnant mice, Indomethacin produced maternal toxicity and death, increased fetal resorptions, and fetal malformations at 0. When rat and mice dams were dosed during the last three days of gestation, Indomethacin produced neuronal necrosis in the offspring at 0.
Based on animal data, prostaglandins have been shown to have an important role in endometrial vascular permeability, blastocyst implantation, and decidualization. In animal studies, administration of prostaglandin synthesis inhibitors such as Indomethacin, resulted in increased pre- and post-implantation loss. Clinical Considerations Labor or Delivery There are no studies on the effects of Indomethacin capsules during labor or delivery.
In animal studies, NSAIDs, including Indomethacin, inhibit prostaglandin synthesis, cause delayed parturition, and increase the incidence of stillbirth. Data Animal Data Reproductive studies were conducted in mice and rats at dosages of 0. In rats and mice, maternal Indomethacin administration of 4. Lactation Risk Summary Based on available published clinical data, Indomethacin may be present in human milk. Based on these levels, the average concentration present in breast milk was estimated to be 0.
In another study Indomethacin levels were measured in breast milk of eight postpartum women using doses of 75 mg daily and the results were used to calculate an estimated infant daily dose.
Females and Males of Reproductive Potential Infertility Females Based on the mechanism of action, the use of prostaglandin-mediated NSAIDs, including Indomethacin capsules, may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women.
If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.
Avoid exposure to sunlight or artificial UV rays sunlamps or tanning beds. Indomethacin can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen minimum SPF 15 and wear protective clothing if you must be out in the sun. What other drugs will affect indomethacin Indocin, Indocin SR? Tell your doctor if you are taking an antidepressant such as citalopram Celexa , duloxetine Cymbalta , escitalopram Lexapro , fluoxetine Prozac, Sarafem, Symbyax , fluvoxamine Luvox , paroxetine Paxil , sertraline Zoloft , or venlafaxine Effexor.
Its use in acute gout attacks and in dysmenorrhea is well-established because in these indications the duration of treatment is limited to a few days only, therefore serious side effects are not likely to occur. People should undergo regular physical examination to detect edema and signs of central nervous side effects. Blood pressure checks will reveal development of hypertension. Periodic serum electrolyte sodium, potassium, chloride measurements, complete blood cell counts and assessment of liver enzymes as well as of creatinine renal function should be performed.
No examinations are necessary if only the topical preparations spray or gel are applied. In women who are pregnant, it has been shown that use of this medication can have an effect of the fetal Baby's heart possibly resulting in fetal death via premature closing of the Ductus arteriosus ; this is rare. Exact human data does not exist, but some fatal human cases, particularly in children and adolescents, have been seen.
Generally, overdose in humans causes drowsiness, dizziness, severe headache, mental confusion, paresthesia , numbness of limbs, nausea and vomiting. Severe gastrointestinal bleeding is also possible. If stomach upset occurs while taking Indomethacin 50mg, take it with food, milk, or an antacid. The dosage is based on your medical condition and response to treatment.
In children, the dosage is also based on weight. To reduce your risk of stomach bleeding and other side effects, take Indomethacin 50mg at the lowest effective dose for the shortest possible time. Do not increase your dose or use Indomethacin 50mg more often or for longer than prescribed. For ongoing conditions such as arthritis, continue taking Indomethacin 50mg as directed.
Discuss the risks and benefits with your doctor or pharmacist. In certain conditions such as arthritis , it may take up to 4 weeks when Indomethacin 50mg is taken regularly before you notice the full benefits. If you are taking Indomethacin 50mg on an "as needed" basis not on a regular schedule , remember that pain medications work best if they are used as the first signs of pain occur.
If you wait until the pain has worsened, the medication may not work as well. Tell your doctor if your condition worsens. Upset stomach, heartburn, headache, drowsiness, or dizziness may occur.
If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed Indomethacin 50mg because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Indomethacin 50mg do not have serious side effects. Indomethacin 50mg may raise your blood pressure.
Check your blood pressure regularly and tell your doctor if the results are high. Tell your doctor right away if any of these unlikely but serious side effects occur: Indomethacin is also used to treat pain in the shoulder caused by bursitis inflammation of a fluid-filled sac in the shoulder joint and tendinitis inflammation of the tissue that connects muscle to bone. Indomethacin immediate-release capsules, suspension liquid and suppositories are also used to treat acute gouty arthritis attacks of severe joint pain and swelling caused by a build-up of certain substances in the joints.
It works by stopping the body's production of a substance that causes pain, fever, and inflammation. HOW should this medicine be used? Indomethacin comes as a capsule, an extended-release long-acting capsule, and a suspension to take by mouth and as a suppository to be used rectally.
Indomethacin capsules and liquid usually are taken two to four times a day. Indomethacin suppositories usually are used two to four times daily. Extended-release capsules are usually taken one or two times a day. Indomethacin capsules, extended-release capsules, and suspension should be taken with food, immediately after meals, or with antacids. Take indomethacin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Take indomethacin exactly as directed.
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