The other ingredients are lactose monohydrate, maize starch, povidone K30, magnesium stearate, macrogol , indigo carmine E , titanium dioxide E and hypromellose. What Phenergan Tablets look like and contents of the pack A pale blue film coated circular tablets with "PN25" on one side and the other side is plain.

The tablets are available in blister packs of 56 tablets. This leaflet does not contain all the information about your medicine. If you have any questions or are not sure about anything, ask your doctor or pharmacist. Leaflet revision and issue date Ref.

To request a copy of this leaflet in Braille, large print or audio please call Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient.

If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist. Solosec Solosec secnidazole is a nitroimidazole antimicrobial for use as a single-dose oral therapy in the Histamine can cause problematic reactions such as anaphylaxis, or more localised ones such as hay fever.

Promethazine can be used to treat the symptoms of both. Promethazine also reduces histamine activity in the vomiting centre of the brain. This area of the brain is in charge of the vomiting reflex and feelings of sickness. One trigger for vomiting that the vomiting centre is activated by is a nerve signal from the vestibular apparatus in the middle ear.

When head movements, such as those experienced when travelling by car or boat, are detected in the vestibular apparatus, it can send signals to the vomiting centre that result in motion sickness.

The symptoms of this include dizziness, vertigo, nausea, and vomiting. Promethazine blocks the histamine receptors in the vomiting centre, meaning such signals from the vestibular apparatus will not trigger these symptoms. Promethazine is a sedating antihistamine, meaning it also causes drowsiness.

This sedating effect is used before minor surgeries. It can also be useful to provide relief for people suffering from sleeping difficulties such as insomnia. Phenergan Elixir is an orange flavoured and sugar free sedating antihistamine, providing relief from hay fever or rashes, and also aiding those experiencing sleeping difficulties. Take ONE tablet the night before the journey. This may be repeated after hours if necessary.

Take TWO tablets the night before the journey. Can be repeated after hours if needed. Take TWO tablets as a single night time dose. Children over 10 years and Adults: Children 5 - 10 years: Swallow 1 25mg tablet at night. Avoid giving in excess of 25mg a day. Adults, elderly and children over 10 years: Initially take 1 tablet of 25mg at night.

You can then increase up to a maximum of 1 25mg tablet twice a day if required. One 5ml spoonful twice each day or as one single dosage of one to three 5ml spoonfuls. Avoid giving in excess of three 5ml spoonfuls a day. Two 5ml spoonfuls twice each day or as one single dosage of one to five 5ml spoonfuls. Avoid giving in excess of five 5ml spoonfuls a day. Initially give two 5ml spoonfuls each day. You can then increase up to a maximum of four 5ml spoonfuls 3 times a day.

For travel sickness Children 2 - 5 years: Take one 5ml spoonful at night before the journey begins to be repeated after hours if needed. Lower Seizure Threshold Promethazine hydrochloride tablets may lower seizure threshold.

It should be used with caution in persons with seizure disorders or in persons who are using concomitant medications, such as narcotics or local anesthetics, which may also affect seizure threshold. Bone-Marrow Depression Promethazine hydrochloride tablets should be used with caution in patients with bone-marrow depression.

Leukopenia and agranulocytosis have been reported, usually when promethazine hydrochloride has been used in association with other known marrow-toxic agents. Neuroleptic Malignant Syndrome A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome NMS has been reported in association with promethazine hydrochloride alone or in combination with antipsychotic drugs. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmias.

The diagnostic evaluation of patients with this syndrome is complicated. In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness e. Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system CNS pathology.

The management of NMS should include 1 immediate discontinuation of promethazine hydrochloride, antipsychotic drugs, if any, and other drugs not essential to concurrent therapy, 2 intensive symptomatic treatment and medical monitoring, and 3 treatment of any concomitant serious medical problems for which specific treatments are available. There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS.

Since recurrences of NMS have been reported with phenothiazines, the reintroduction of promethazine hydrochloride should be carefully considered. Use in Pediatric Patients: Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine HCl in pediatric patients.

In pediatric patients who are acutely ill associated with dehydration, there is an increased susceptibility to dystonias with the use of promethazine HCl. Other Considerations Administration of promethazine HCl has been associated with reported cholestatic jaundice.

Precautions General Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction. Promethazine HCl Tablets should be used cautiously in persons with cardiovascular disease or with impairment of liver function.

Pediatric patients should be supervised to avoid potential harm in bike riding or in other hazardous activities. Patients should be advised to report any involuntary muscle movements. Avoid prolonged exposure to the sun. When given concomitantly with promethazine hydrochloride tablets, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half.

Dosage must be individualized. Excessive amounts of promethazine hydrochloride relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain. Epinephrine Because of the potential for promethazine hydrochloride to reverse epinephrine's vasopressor effect, epinephrine should NOT be used to treat hypotension associated with promethazine hydrochloride tablets overdose.

Anticholinergics Concomitant use of other agents with anticholinergic properties should be undertaken with caution. This possibility should be considered with promethazine hydrochloride tablets. Pregnancy Tests Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations.

Glucose Tolerance Test An increase in blood glucose has been reported in patients receiving promethazine hydrochloride. Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term animal studies have not been performed to assess the carcinogenic potential of promethazine, nor are there other animal or human data concerning carcinogenicity, mutagenicity, or impairment of fertility with this drug.

Promethazine was nonmutagenic in the Salmonella test system of Ames. Pregnancy Category C Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6. These doses are from approximately 2. Specific studies to test the action of the drug on parturition, lactation, and development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on these parameters.

Although antihistamines have been found to produce fetal mortality in rodents, the pharmacological effects of histamine in the rodent do not parallel those in man. There are no adequate and well controlled studies of promethazine in pregnant women. Promethazine hydrochloride tablets should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nonteratogenic Effects Promethazine administered to a pregnant woman within 2 weeks of delivery may inhibit platelet aggregation in the newborn. Limited data suggest that use of promethazine hydrochloride during labor and delivery does not have an appreciable effect on the duration of labor or delivery and does not increase the risk of need for intervention in the newborn.

The effect on later growth and development of the newborn is unknown. See also Nonteratogenic Effects. Nursing Mothers It is not known whether promethazine hydrochloride is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from promethazine hydrochloride tablets, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

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