The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For oral dosage forms liquid or tablets: For treatment of bacterial infections: Adults and children weighing 40 kilograms kg or more— milligrams mg of sulfamethoxazole and mg of trimethoprim every 12 hours for 10 to 14 days. Your doctor may adjust this dose if needed. Children 2 months of age and older, and weighing up to 40 kg—Dose is based on body weight and must be determined by your doctor.
The usual dose is 40 milligrams mg per kilogram of body weight of sulfamethoxazole and 8 milligrams mg per kilogram of body weight of trimethoprim , given in two divided doses every 12 hours for 10 days. Infants younger than 2 months of age—Use is not recommended. Adults and children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. Adult doses of 6 to 8 tablets daily for up to 3 months have been used one tablet contains mg sulfamethoxazole and 80 mg trimethoprim.
There is no consensus on the most appropriate dosage for the treatment or prophylaxis of this condition. The decision should be based on clinical experience. For prophylaxis, however, the dosages suggested for prevention of Pneumocystis jiroveci pneumonitis may be appropriate. Children aged 12 years and under with renal impairment: No data are available relating to dosage in children aged 12 years and under with impaired renal function.
Children aged 12 years and under with hepatic impairment: No data are available relating to dosage in children aged 12 years and under with impaired hepatic function. Contra-indicated in patients showing marked liver parenchymal damage. Contra-indicated in severe renal insufficiency where repeated measurements of the plasma concentration cannot be performed. Early withdrawal is associated with a better prognosis.
Particular care is always advisable when treating elderly patients because, as a group, they are more susceptible to adverse reactions and more likely to suffer serious effects as a result particularly when complicating conditions exist, e. An adequate urinary output should be maintained at all times. Evidence of crystalluria in vivo is rare, although sulphonamide crystals have been noted in cooled urine from treated patients. In patients suffering from malnutrition the risk may be increased.
Regular monthly blood counts are advisable when Septrin is given for long periods, or to folate deficient patients or to the elderly, since there exists a possibility of asymptomatic changes in haematological laboratory indices due to lack of available folate.
In glucosephosphate dehydrogenase GPD deficient patients haemolysis may occur. Septrin should be given with caution to patients with severe allergy or bronchial asthma. Septrin should not be used in the treatment of streptococcal pharyngitis due to Group A beta-haemolytic streptococci; eradication of these organisms from the oropharynx is less effective than with penicillin. Adults and children 2 months of age and older—Dose is based on body weight and must be determined by your doctor.
The usual dose is 75 to milligrams mg per kilogram of body weight of sulfamethoxazole and 15 to 20 milligrams mg per kilogram of body weight of trimethoprim each day, given in equally divided doses every 6 hours for 14 to 21 days.
Children younger than 2 months of age—Use is not recommended. Adults— milligrams mg of sulfamethoxazole and mg of trimethoprim once a day. Children 2 months of age and older—Dose is based on body size and must be determined by your doctor.
The usual dose is mg of sulfamethoxazole and mg of trimethoprim per square meter m[2] of body surface each day. This is given in equally divided doses two times a day for 3 days a week on consecutive days eg, Monday, Tuesday, Wednesday. However, the dose is usually not more than mg of sulfamethoxazole and mg of trimethoprim per day.
Adults— milligrams mg of sulfamethoxazole and mg of trimethoprim every 12 hours for 5 days. Children 2 months of age and older—Use and dose must be determined by your doctor. In some rabbit studies, an overall increase in fetal loss dead and resorbed and malformed conceptuses was associated with doses of trimethoprim 6 times the human therapeutic dose. While there are no large, well-controlled studies on the use of sulfamethoxazole and trimethoprim in pregnant women, Brumfitt and Pursell,9 in a retrospective study, reported the outcome of pregnancies during which the mother received either placebo or sulfamethoxazole and trimethoprim.
The incidence of congenital abnormalities was 4. There were no abnormalities in the 10 children whose mothers received the drug during the first trimester. In a separate survey, Brumfitt and Pursell also found no congenital abnormalities in 35 children whose mothers had received oral sulfamethoxazole and trimethoprim at the time of conception or shortly thereafter.
Because sulfamethoxazole and trimethoprim may interfere with folic acid metabolism, BACTRIM should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Clinical studies of BACTRIM did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. There may be an increased risk of severe adverse reactions in elderly patients, particularly when complicating conditions exist, e.
In those concurrently receiving certain diuretics, primarily thiazides, an increased incidence of thrombocytopenia with purpura has been reported.
Hematological changes indicative of folic acid deficiency may occur in elderly patients. The trimethoprim component of BACTRIM may cause hyperkalemia when administered to patients with underlying disorders of potassium metabolism, with renal insufficiency or when given concomitantly with drugs known to induce hyperkalemia, such as angiotensin converting enzyme inhibitors.
Bactrim Tablets contain 1. Bactrim DS Tablets contain 3. Pharmacokinetics parameters for sulfamethoxazole were similar for geriatric subjects and younger adult subjects. Agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, neutropenia, hemolytic anemia, megaloblastic anemia, hypoprothrombinemia, methemoglobinemia, eosinophilia. Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylaxis, allergic myocarditis, erythema multiforme, exfoliative dermatitis, angioedema, drug fever, chills, Henoch-Schoenlein purpura, serum sickness-like syndrome, generalized allergic reactions, generalized skin eruptions, photosensitivity, conjunctival and scleral injection, pruritus, urticaria and rash.
In addition, periarteritis nodosa and systemic lupus erythematosus have been reported. Hepatitis including cholestatic jaundice and hepatic necrosis , elevation of serum transaminase and bilirubin, pseudomembranous enterocolitis, pancreatitis, stomatitis, glossitis, nausea, emesis, abdominal pain, diarrhea, anorexia.
Renal failure, interstitial nephritis, BUN and serum creatinine elevation, toxic nephrosis with oliguria and anuria, crystalluria and nephrotoxicity in association with cyclosporine. Aseptic meningitis, convulsions, peripheral neuritis, ataxia, vertigo, tinnitus, headache. Hallucinations, depression, apathy, nervousness.
Long-term studies in animals to evaluate carcinogenic potential have not been conducted with sulfamethoxazole and trimethoprim. For trospium, monitor for anticholinergic effects, such as dry mouth, constipation, blurred vision, urinary retention, or increased CNS effects which are not frequent when the drug is used alone. In addition, adverse events may vary in their incidence depending on the indication. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with sulfamethoxazole; trimethoprim include bedaquiline. Carcinogenesis, Mutagenesis, Impairment of Fertility: Minor Concomitant use of sulfamethoxazole; trimethoprim and lumacaftor; ivacaftor may alter sulfamethoxazole; trimethoprim, SMX-TMP, Cotrimoxazole exposure, bactrim 200 40mg dosis. Infuse over a period of 60—90 minutes. Trimethoprim interferes with assays for serum methotrexate when dihydrofolate reductase from Lactobacillus casei is used in the assay. During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances. Moderate The incidence of marijuana associated adverse effects may change following coadministration with sulfamethoxazole.
Minor Use caution if sulfamethoxazole and aprepitant are used concurrently and monitor for a possible decrease in the efficacy dosis sulfamethoxazole. Coagulation should be monitored. Monitor for therapeutic response to therapy and increased rifampin toxicity Rilpivirine: Concomitant use of fenofibric acid with CYP2C9 substrates, such as sulfamethoxazole, has not been formally bactrim. Coadministration may increase the risk of sulfamethoxazole toxicity, bactrim 200 40mg dosis. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with sulfamethoxazole; trimethoprim include artemether. Patients who are "slow acetylators" may be more prone to idiosyncratic reactions to sulfonamides. Predictions about the interaction can be made based on the metabolic pathways of both drugs. The toxicity of methotrexate may increase, especially in the presence of risk factors such as old age, hypoalbuminemia, impaired renal function and decreased bone marrow reserve, and in patients receiving high doses of methotrexate. Moderate Use caution if coadministration of capecitabine with sulfamethoxazole is necessary, and monitor for an increase in 200 adverse reactions. Trimethoprim is 40mg into 11 different elocon voide 1mg, with the major metabolites being the 1- and 3-oxides and the 3- and 4-hydroxy derivatives.
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