GH deficiency can be treated through growth hormone replacement , injections of growth hormone, or radiation or surgical treatment of tumors. Contents Classification Edit Growth hormone deficiency can be congenital or acquired in childhood or adult life.
It can be partial or complete. It is usually permanent, but sometimes transient. It may be an isolated deficiency or occur in association with deficiencies of other pituitary hormones. Human growth hormone stimulates liver cells to produce polypeptide molecules known as somatomedins.
These agents affect all body systems. Some of their functions are listed below: Muscular development; Improvement of the skeletal structure; Regulation of various functions related to metabolism; Stimulation of normal brain function; Improvement of cardiac function. The secretion of human growth hormone decreases with age. This may lead to a number of undesirable symptoms, which are usually associated with aging processes: Anabolic effect — HGH causes muscle growth.
HGH reduces fat accumulation. Human growth hormone has a rejuvenating effect. This agent stimulates the growth of internal organs in case of age-related atrophy. The improvement in lean body mass is associated with increased protein synthesis, muscle mass and muscle function.
Total body fat mass also decreases after 6 months of GH administration. The decline in fat mass is most significant in visceral and trunk locations as compared to the arms, neck and legs, suggesting that GH replacement therapy will reverse the truncal redistribution of fat mass associated with GH deficiency and impact on cardiovascular risk.
Lipid Metabolism - GH replacement in adults may have a beneficial effect on lipids. Subsequent trials have confirmed this benefit in aggregate, but it must be noted that dramatic changes in serum lipid levels are not consistently seen with GH administration.
GH replacement therapy has also been shown to consistently reduce hsCRP levels in both men and women with hypopituitarism. Bone Density - The potential role of GH in the maintenance of the skeleton has recently been investigated. GH is known to stimulate osteoblast proliferation and thymidine incorporation in vitro. Furthermore, GH stimulates systemic and local production of insulin-like growth factor 1 IGF-1 , also anabolic to bone. It more commonly affects children than adults.
The pituitary gland is a small gland about the size of a pea. Some of these hormones control thyroid activity and body temperature. GHD occurs in roughly 1 in 7, births. The condition is also a symptom of several genetic diseases, including Turner syndrome and Prader-Willi syndrome.
You may grow concerned if your child is not meeting height and weight growth standards. Growth hormone deficiency is treatable. Children who are diagnosed early often recover very well.
If left untreated, the condition can result in shorter-than-average height and delayed puberty.
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