Flexeril 5mg

It is ineffective in muscle spasm due to central nervous system disease. Cyclobenzaprine reduced or abolished skeletal muscle hyperactivity in several animal models. Animal studies indicate that cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle.

Such studies show that cyclobenzaprine acts primarily within the central nervous system at brain stem as opposed to spinal cord levels, although its action on the latter may contribute to its overall skeletal muscle relaxant activity. Pharmacological studies in animals showed a similarity between the effects of cyclobenzaprine and the structurally related tricyclic antidepressants, including reserpine antagonism, norepinephrine potentiation, potent peripheral and central anticholinergic effects, and sedation.

Cyclobenzaprine caused slight to moderate increase in heart rate in animals. Cyclobenzaprine exhibits linear pharmacokinetics over the dose range 2. It is highly bound to plasma proteins. Drug accumulates when dosed three times a day, reaching steady-state within days at plasma concentrations about four-fold higher than after a single dose.

At steady state in healthy subjects receiving 10 mg t. Cyclobenzaprine is extensively metabolized, and is excreted primarily as glucuronides via the kidney.

Cytochromes P 3A4, 1A2, and, to a lesser extent, 2D6, mediate N-demethylation, one of the oxidative pathways for cyclobenzaprine.

The plasma concentration of cyclobenzaprine is generally higher in the elderly and in patients with hepatic impairment. Elderly male subjects had the highest observed mean increase, approximately 2. In light of these findings, therapy with Flexeril in the elderly should be initiated with a 5 mg dose and titrated slowly upward. Hepatic Impairment In a pharmacokinetic study of sixteen subjects with hepatic impairment 15 mild, 1 moderate per Child-Pugh score , both AUC and Cmax were approximately double the values seen in the healthy control group.

Based on the findings, Flexeril should be used with caution in subjects with mild hepatic impairment starting with the 5 mg dose and titrating slowly upward. Due to the lack of data in subjects with more severe hepatic insufficiency, the use of Flexeril in subjects with moderate to severe impairment is not recommended. No significant effect on plasma levels or bioavailability of Flexeril or aspirin was noted when single or multiple doses of the two drugs were administered concomitantly.

Concomitant administration of Flexeril and naproxen or diflunisal was well tolerated with no reported unexpected adverse effects. However combination therapy of Flexeril with naproxen was associated with more side effects than therapy with naproxen alone, primarily in the form of drowsiness.

No well-controlled studies have been performed to indicate that Flexeril enhances the clinical effect of aspirin or other analgesics, or whether analgesics enhance the clinical effect of Flexeril in acute musculoskeletal conditions. Clinical Studies Eight double-blind controlled clinical studies were performed in patients comparing Flexeril 10 mg, diazepam 1 , and placebo.

Muscle spasm, local pain and tenderness, limitation of motion, and restriction in activities of daily living were evaluated. In three of these studies there was a significantly greater improvement with Flexeril than with diazepam, while in the other studies the improvement following both treatments was comparable. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Cyamemazine. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Cyclizine.

Approved The metabolism of Cyclobenzaprine can be decreased when combined with Cyclosporine. Approved, Investigational, Vet Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Cyproheptadine. Approved The serum concentration of Cyclobenzaprine can be decreased when it is combined with Cyproterone acetate. Approved, Investigational The serum concentration of Cyclobenzaprine can be increased when it is combined with Dabigatran etexilate.

Approved The serum concentration of Cyclobenzaprine can be decreased when it is combined with Dabrafenib. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dantrolene. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dapiprazole. Approved The risk or severity of adverse effects can be increased when Dapoxetine is combined with Cyclobenzaprine.

Investigational The serum concentration of Cyclobenzaprine can be increased when it is combined with Darexaban. Investigational The metabolism of Cyclobenzaprine can be decreased when combined with Darifenacin. Approved, Investigational The serum concentration of Cyclobenzaprine can be increased when it is combined with Darunavir. Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Dasatinib.

Approved, Investigational The serum concentration of Cyclobenzaprine can be decreased when it is combined with Deferasirox. Approved, Investigational The serum concentration of Cyclobenzaprine can be increased when it is combined with Delanzomib. Investigational The serum concentration of Cyclobenzaprine can be increased when it is combined with Delapril. Experimental The metabolism of Cyclobenzaprine can be decreased when combined with Delavirdine. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Deramciclane.

Investigational The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Desflurane. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Desipramine. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Desloratadine.

Approved, Investigational The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Desmopressin. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Desvenlafaxine. Approved Detomidine The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Detomidine.

Vet Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dexbrompheniramine. Approved Cyclobenzaprine may decrease the antihypertensive activities of Dexmedetomidine. Approved, Vet Approved The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Cyclobenzaprine. Approved Cyclobenzaprine may increase the stimulatory activities of Dextroamphetamine. Approved, Illicit The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Cyclobenzaprine.

Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dextromoramide. Experimental, Illicit The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dextropropoxyphene.

Approved, Illicit, Withdrawn The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dezocine. Approved The risk or severity of adverse effects can be increased when Diazepam is combined with Cyclobenzaprine.

Approved, Illicit, Vet Approved Cyclobenzaprine may increase the anticoagulant activities of Dicoumarol. Approved Diethyl ether The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Diethyl ether. Experimental Cyclobenzaprine may increase the stimulatory activities of Diethylpropion. Approved, Illicit The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Difenoxin. Approved, Illicit The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dihydrocodeine.

Approved, Illicit Cyclobenzaprine may decrease the antihypertensive activities of Dihydroergotamine. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dihydroetorphine. Experimental, Illicit The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dihydromorphine. Experimental, Illicit The metabolism of Cyclobenzaprine can be decreased when combined with Diltiazem.

Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dimenhydrinate. Approved Cyclobenzaprine may increase the anticoagulant activities of Diphenadione.

Experimental The metabolism of Cyclobenzaprine can be decreased when combined with Diphenhydramine. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Diphenoxylate.

Approved, Illicit Cyclobenzaprine may decrease the antihypertensive activities of Dipivefrin. Approved Dixyrazine The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dixyrazine. Experimental The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dobutamine.

Approved Dolasetron may increase the serotonergic activities of Cyclobenzaprine. Approved Doramectin The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Doramectin.

Vet Approved The metabolism of Cyclobenzaprine can be decreased when combined with Dosulepin. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Doxepin. Approved The metabolism of Cyclobenzaprine can be decreased when combined with Doxycycline. Investigational Dronabinol may increase the central nervous system depressant CNS depressant activities of Cyclobenzaprine. Approved, Illicit The metabolism of Cyclobenzaprine can be decreased when combined with Dronedarone.

Approved Droperidol may increase the central nervous system depressant CNS depressant activities of Cyclobenzaprine. Approved, Vet Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Drotebanol.

Experimental, Illicit Cyclobenzaprine may decrease the antihypertensive activities of Droxidopa. Approved, Investigational Duloxetine may increase the serotonergic activities of Cyclobenzaprine. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dyclonine. Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Ecabet.

Approved, Investigational The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ecgonine. Experimental, Illicit The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ecopipam. Investigational The serum concentration of Cyclobenzaprine can be increased when it is combined with Edoxaban. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Efavirenz.

Approved, Investigational The serum concentration of Cyclobenzaprine can be increased when it is combined with Elafin. Investigational The risk or severity of adverse effects can be increased when Eletriptan is combined with Cyclobenzaprine. Approved, Investigational The metabolism of Cyclobenzaprine can be decreased when combined with Eliglustat.

Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Eltanolone. Investigational The serum concentration of Cyclobenzaprine can be increased when it is combined with Enalapril. Approved, Vet Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Enalaprilat. Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Enalkiren.

Experimental The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Enflurane. Approved, Investigational, Vet Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Entacapone. Approved, Investigational The serum concentration of Cyclobenzaprine can be decreased when it is combined with Enzalutamide. Approved Cyclobenzaprine may decrease the antihypertensive activities of Ephedra.

Approved, Nutraceutical, Withdrawn The serum concentration of Cyclobenzaprine can be increased when it is combined with Epigallocatechin Gallate. Investigational Cyclobenzaprine may decrease the antihypertensive activities of Epinephrine. Approved, Vet Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ergoloid mesylate.

Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ergonovine. Approved Cyclobenzaprine may decrease the antihypertensive activities of Ergotamine. Approved The metabolism of Cyclobenzaprine can be decreased when combined with Erythromycin. Approved, Vet Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Escitalopram.

Approved, Investigational The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Estazolam. Approved, Illicit The risk or severity of adverse effects can be increased when Eszopiclone is combined with Cyclobenzaprine.

Approved Cyclobenzaprine may increase the central nervous system depressant CNS depressant activities of Ethanol. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ethchlorvynol. Approved, Illicit, Withdrawn The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ethosuximide. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ethotoin.

Approved Cyclobenzaprine may increase the anticoagulant activities of Ethyl biscoumacetate. Withdrawn The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ethyl carbamate. Withdrawn The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ethyl chloride. Experimental The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ethyl loflazepate. Approved, Illicit The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ethylmorphine.

Approved, Illicit The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Etidocaine.

Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Etifoxine. Withdrawn The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Etizolam.

Approved Cyclobenzaprine may decrease the antihypertensive activities of Etomidate. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Etoperidone. Withdrawn The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Etorphine.

Illicit, Vet Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ezogabine. Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Faldaprevir.

Investigational The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Felbamate. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Fencamfamine. Approved, Illicit, Withdrawn The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Fenoterol.

Approved The risk or severity of adverse effects can be increased when Fentanyl is combined with Cyclobenzaprine. Approved, Illicit, Investigational, Vet Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Fexofenadine. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Flibanserin.

Approved Fluanisone The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Fluanisone. Experimental The metabolism of Cyclobenzaprine can be decreased when combined with Fluconazole. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Fludiazepam. Approved, Illicit Cyclobenzaprine may increase the anticoagulant activities of Fluindione. Investigational The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Flunarizine.

Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Flunitrazepam. Approved, Illicit The risk or severity of adverse effects can be increased when Fluoxetine is combined with Cyclobenzaprine. Approved, Vet Approved The risk or severity of adverse effects can be increased when Flupentixol is combined with Cyclobenzaprine. Approved, Withdrawn The risk or severity of adverse effects can be increased when Fluphenazine is combined with Cyclobenzaprine.

Approved The risk or severity of adverse effects can be increased when Flurazepam is combined with Cyclobenzaprine. Approved, Illicit The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Fluspirilene. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Fluticasone propionate. Approved The risk or severity of adverse effects can be increased when Fluvoxamine is combined with Cyclobenzaprine.

Approved, Investigational The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Formoterol. Approved, Investigational The serum concentration of Cyclobenzaprine can be increased when it is combined with Fosamprenavir.

Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Fosaprepitant. Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Fosinopril. Approved The metabolism of Cyclobenzaprine can be increased when combined with Fosphenytoin. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Fospropofol.

Approved, Illicit The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Frovatriptan. Approved, Investigational Cyclobenzaprine may increase the serotonergic activities of Furazolidone. Approved, Vet Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Fusidic Acid. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Gabapentin. Approved, Investigational The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Gabapentin Enacarbil.

Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Gabexate. Investigational The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Gamma Hydroxybutyric Acid.

Approved, Illicit The serum concentration of Cyclobenzaprine can be increased when it is combined with Geldanamycin. Experimental Cyclobenzaprine may increase the stimulatory activities of Gepefrine. Experimental The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Gepirone. Investigational The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Glutethimide.

Approved, Illicit The serum concentration of Cyclobenzaprine can be increased when it is combined with GM Experimental Granisetron may increase the serotonergic activities of Cyclobenzaprine. Approved, Investigational Cyclobenzaprine may decrease the antihypertensive activities of Guanabenz.

Approved Cyclobenzaprine may decrease the antihypertensive activities of Guanfacine. Approved, Investigational The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Halazepam.

Approved, Illicit, Withdrawn The metabolism of Cyclobenzaprine can be decreased when combined with Haloperidol. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Halothane.

Approved, Vet Approved Cyclobenzaprine may increase the serotonergic activities of Harmaline. Experimental The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Heroin.

Approved, Illicit The metabolism of Cyclobenzaprine can be increased when combined with Hexobarbital. Approved Cyclobenzaprine may increase the serotonergic activities of Hydracarbazine.

Experimental Cyclobenzaprine may increase the central nervous system depressant CNS depressant activities of Hydrocodone. Approved, Illicit The risk or severity of adverse effects can be increased when Hydromorphone is combined with Cyclobenzaprine. Approved, Illicit Cyclobenzaprine may increase the stimulatory activities of Hydroxyamphetamine. Approved Hydroxyzine may increase the central nervous system depressant CNS depressant activities of Cyclobenzaprine.

Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Idelalisib. Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Idraparinux. Investigational The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Iloperidone. Approved The metabolism of Cyclobenzaprine can be decreased when combined with Imatinib. Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Imidapril.

Investigational The risk or severity of adverse effects can be increased when Imipramine is combined with Cyclobenzaprine. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Indacaterol.

Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Indalpine. Investigational, Withdrawn The metabolism of Cyclobenzaprine can be decreased when combined with Indinavir.

Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Indiplon. Investigational The therapeutic efficacy of Iobenguane can be decreased when used in combination with Cyclobenzaprine. Approved Cyclobenzaprine may increase the stimulatory activities of Iofetamine I Approved Cyclobenzaprine may increase the serotonergic activities of Iproclozide.

Withdrawn Cyclobenzaprine may increase the serotonergic activities of Iproniazid. Withdrawn The metabolism of Cyclobenzaprine can be decreased when combined with Isavuconazonium. Approved, Investigational Cyclobenzaprine may increase the serotonergic activities of Isocarboxazid. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Isoetarine. Approved The risk or severity of adverse effects can be increased when Isoflurane is combined with Cyclobenzaprine.

Approved, Vet Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Isoflurophate. Approved, Withdrawn The metabolism of Cyclobenzaprine can be decreased when combined with Isoniazid. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Isoprenaline.

Approved The metabolism of Cyclobenzaprine can be decreased when combined with Isradipine. Approved The metabolism of Cyclobenzaprine can be decreased when combined with Itraconazole.

Approved, Investigational The serum concentration of Cyclobenzaprine can be increased when it is combined with Ivacaftor. Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Ixazomib.

Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ketamine. Approved, Vet Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ketazolam. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ketobemidone. Approved The metabolism of Cyclobenzaprine can be decreased when combined with Ketoconazole. Approved, Investigational The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Lamotrigine.

Approved, Investigational The serum concentration of Cyclobenzaprine can be increased when it is combined with Lepirudin. Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Letaxaban. Investigational The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Levetiracetam. Approved, Investigational The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Levobupivacaine.

Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Levocabastine. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Levocetirizine.

Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Levodopa. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Levomethadyl Acetate. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Levomilnacipran. Approved Cyclobenzaprine may decrease the antihypertensive activities of Levonordefrin.

Approved The risk or severity of adverse effects can be increased when Levorphanol is combined with Cyclobenzaprine. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Levosalbutamol. Approved Levothyroxine may increase the arrhythmogenic activities of Cyclobenzaprine. Approved The metabolism of Cyclobenzaprine can be decreased when combined with Lidocaine.

Approved, Vet Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Linagliptin. Approved Linezolid may increase the serotonergic activities of Cyclobenzaprine. Approved, Investigational Liothyronine may increase the arrhythmogenic activities of Cyclobenzaprine. Approved, Vet Approved Liotrix may increase the arrhythmogenic activities of Cyclobenzaprine.

Approved Cyclobenzaprine may increase the stimulatory activities of Lisdexamfetamine. Approved, Investigational The serum concentration of Cyclobenzaprine can be increased when it is combined with Lisinopril. Approved, Investigational Lithium may increase the neurotoxic activities of Cyclobenzaprine. Approved The metabolism of Cyclobenzaprine can be decreased when combined with Lobeglitazone. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Lofentanil.

Illicit Cyclobenzaprine may decrease the antihypertensive activities of Lofexidine. Approved, Investigational The metabolism of Cyclobenzaprine can be decreased when combined with Lopinavir. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Loprazolam. Experimental The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Loratadine. Approved The risk or severity of adverse effects can be increased when Lorazepam is combined with Cyclobenzaprine.

Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Lorcaserin. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Lormetazepam. Approved The metabolism of Cyclobenzaprine can be decreased when combined with Lovastatin. Approved, Investigational The risk or severity of adverse effects can be increased when Loxapine is combined with Cyclobenzaprine.

Approved The serum concentration of Cyclobenzaprine can be increased when it is combined with Luliconazole. Approved The metabolism of Cyclobenzaprine can be increased when combined with Lumacaftor. Approved The metabolism of Cyclobenzaprine can be decreased when combined with Lumefantrine. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Lurasidone. Approved Magnesium Sulfate may increase the central nervous system depressant CNS depressant activities of Cyclobenzaprine.

Approved, Vet Approved The metabolism of Cyclobenzaprine can be decreased when combined with Manidipine. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Maprotiline.

Approved Cyclobenzaprine may increase the serotonergic activities of Mebanazine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor. Where can I get more information? Your pharmacist can provide more information about cyclobenzaprine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.

Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient.

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