Each mL contains 2 mg dexamethasone. As supportive therapy, dexamethasone may be used in the management of various rheumatic, allergic, dermatologic, and other diseases known to be responsive to anti-inflammatory corticosteroids.

Dexamethasone Solution may be used intravenously as supportive therapy when an immediate hormonal response is required. Bovine Ketosis Dexamethasone Solution is offered for the treatment of primary ketosis. The gluconeogenic effects of dexamethasone, when administered intramuscularly, are generally noted within the first 6 to 12 hours.

When Dexamethasone Solution is used intravenously, the effects may be noted sooner. Blood sugar levels rise to normal levels rapidly and generally rise to above normal levels within 12 to 24 hours. Make sure laboratory personnel and all your doctors know you use this drug. Does Dexamethasone interact with other medications? Overdose If someone has overdosed and has serious symptoms such as passing out or trouble breathing , call Otherwise, call a poison control center right away.

US residents can call their local poison control center at Canada residents can call a provincial poison control center. Notes Do not share this medication with others.

Consult your doctor for more details. Talk with your doctor about making changes to your lifestyle that may decrease the side effects of this medication e. Missed Dose If you are taking this medication daily and on a regular schedule, and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. Do not double the dose to catch up. If you are taking this medication every other day or are slowly reducing your dose, and you miss a dose, then contact your doctor or pharmacist right away to establish a new dosing schedule.

Storage Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.

Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Avoid performing other diagnostic procedures on the day of the test, such as radiographs or an abdominal ultrasound. If one must do one of these procedures on the same day that the LDDST is run, the radiography or ultrasonography should be performed a minimum of 2 hours before the start of the LDDST to allow the cortisol concentrations to return to baseline values 8.

Even more importantly, anesthesia for even minor procedures e. In dogs that become highly stressed while in the hospital, tranquilizers and sedatives can not be administered before or during the LDDST. In highly stressed or agitated dogs, one option is to have the owner stay with the hospitalized dog in a quiet area of the hospital during the testing day. If neither of those options are feasible, the owner can take the dog out of the hospital after one collects the basal cortisol sample and injects the dexamethasone, then returns at 4 hours and again at 8 hours for the post-dexamethasone cortisol samples.

Treatment with dexamethasone may be initiated no sooner than 1 week after completion of conivaptan therapy. In addition, conivaptan has been associated with hypokalemia 9. Although not studied, consider the potential for additive hypokalemic effects if conivaptan is coadministered with drugs known to induce hypokalemia, such as corticosteroids.

Major Patients pretreated with dexamethasone have demonstrated an inhibited or blunted response to corticotropin, ovine. Patients receiving corticotropin, ovine should not be pretreated with dexamethasone; no specific guidelines are available. Moderate Monitor for steroid-related adverse reactions if coadministration of crizotinib with dexamethasone is necessary due to increased dexamethasone exposure.

Major Use dabrafenib and dexamethasone together with caution; concentrations of either agent may be decreased. Use an alternate agent in place of dexamethasone if possible. If concomitant use cannot be avoided, monitor patients for loss of dexamethasone efficacy. Taking these drugs together may decrease daclatasvir serum concentrations, potentially resulting in reduced antiviral efficacy and antimicrobial resistance.

Conversely, the therapeutic effects of dexamethasone, a P-glycoprotein P-gp substrate, may be increased by daclatasvir, a P-gp inhibitor. Moderate Systemic corticosteroids increase blood glucose levels; a potential pharmacodynamic interaction exists between corticosteroids and all antidiabetic agents.

Diabetic patients who are administered systemic corticosteroid therapy may require an adjustment in the dosing of the antidiabetic agent. Blood lactate concentrations and the lactate to pyruvate ratio increased when metformin was coadministered with corticosteroids e. Elevated lactic acid concentrations are associated with an increased risk of lactic acidosis, so patients on metformin concurrently with systemic steroids should be monitored closely.

Moderate The metabolism of dapsone may be accelerated when administered concurrently with dexamethasone, a known inducer of CYP3A4. Coadministration is expected to decrease the plasma concentration of dapsone and increase the formation of dapsone hydroxylamine a metabolite associated with hemolysis. If these drugs must be administered together, closely monitor for a reduction in dapsone efficacy and signs of hemolytic anemia.

Major Avoid concurrent use of darunavir with dexamethasone. Coadministration may result in a reduction of antiretroviral efficacy and the potential development of viral resistance to darunavir; consider use of an alternative corticosteroid.

Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir: Severe Concurrent administration of dexamethasone with dasabuvir; ombitasvir; paritaprevir; ritonavir is contraindicated. Taking these drugs together could result in elevated dexamethasone plasma concentrations and decreased concentrations of dasabuvir, paritaprevir, and ritonavir. Antiviral efficacy could be affected. Both paritaprevir and dasabuvir minor are CYP3A4 substrates. Severe Concurrent administration of dexamethasone with dasabuvir; ombitasvir; paritaprevir; ritonavir or ombitasvir; paritaprevir; ritonavir is contraindicated.

Moderate Close monitoring of therapeutic and adverse effects is required when dexamethasone is coadministered with ritonavir. Moderate Because gastric ulceration and GI bleeding have been reported in patients taking deferasirox, use caution when coadministering with other drugs known to increase the risk of peptic ulcers or gastric hemorrhage including corticosteroids. Major Avoid concomitant use of deflazacort and dexamethasone.

Concurrent use may significantly decrease concentrations of desDFZ, the active metabolite of deflazacort, resulting in loss of efficacy. Minor Since dexamethasone may induce metabolism of delavirdine, concomitant use of these agents should be done with caution. Delavirdine therapy may be less effective due to decreased plasma levels in patients taking these drugs concomitantly.

Moderate The safety and efficacy of denosumab use in patients with immunosuppression have not been evaluated. Patients receiving immunosuppressives along with denosumab may be at a greater risk of developing an infection. Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia. Desmopressin can be started or resumed 3 days or 5 half-lives after the corticosteroid is discontinued, whichever is longer.

Moderate Monitor for decreased efficacy of dexlansoprazole if coadministration of dexamethasone is necessary. The manufacturer of dexlansoprazole recommends avoidance with strong inducers because decreased exposure of dexlansoprazole can occur. Inducers of CYP3A4 such as dexamethasone may increase hepatic elimination of quinidine with the potential for reduced efficacy of quinidine.

Moderate Hypokalemia, hypomagnesemia, or hypercalcemia increase digoxin's effect. Corticosteroids can precipitate digoxin toxicity via their effect on electrolyte balance. It is recommended that serum potassium, magnesium, and calcium be monitored regularly in patients receiving digoxin.

Major Corticosteroids can cause increases in blood pressure, sodium and water retention, and hypokalemia, predisposing patients to interactions with certain other medications. Corticosteroid-induced hypokalemia could also enhance the proarrhythmic effects of dofetilide.

Moderate Use caution if coadministration of dronabinol with dexamethasone is necessary, and monitor for a decrease in the efficacy of dronabinol. Concomitant use may result in decreased plasma concentrations of dronabinol. Coadministration of CYP3A4 inducers, such as dexamethasone, with dronedarone may result in reduced plasma concentration and subsequent reduced effectiveness of dronedarone therapy; the plasma concentrations of dexamethasone may also be increased.

Moderate Caution is advised when using droperidol in combination with corticosteroids which may lead to electrolyte abnormalities, especially hypokalemia or hypomagnesemia, as such abnormalities may increase the risk for QT prolongation or cardiac arrhythmias.

Moderate Echinacea possesses immunostimulatory activity and may theoretically reduce the response to immunosuppressant drugs like corticosteroids. For some patients who are using corticosteroids for serious illness, such as cancer or organ transplant, this potential interaction may result in the preferable avoidance of Echinacea. Although documentation is lacking, coadministration of echinacea with immunosuppressants is not recommended by some resources.

Minor In vitro studies indicate that corticosteroids inhibit the antifungal activity of econazole against C. When the concentration of the corticosteroid was equal to or greater than that of econazole on a weight basis, the antifungal activity of econazole was substantially inhibited.

When the corticosteroid concentration was one-tenth that of econazole, no inhibition of antifungal activity was observed. Major Patients receiving immunosuppressives should not receive concurrent therapy with efalizumab because of the possibility of increased infections and malignancies. Major If possible, avoid concurrent administration of elbasvir with dexamethasone.

Use of these drugs together is expected to decrease the plasma concentrations of elbasvir, and may result in decreased virologic response.

Major If possible, avoid concurrent administration of grazoprevir with dexamethasone. Use of these drugs together is expected to decrease the plasma concentrations of grazoprevir, and may result in decreased virologic response. Moderate Coadministration of dexamethasone and eliglustat may result in increased plasma concentrations of dexamethasone.

Monitor patients closely for corticosteroid-related adverse effects; if appropriate, consider reducing the dexamethasone dosage and titrating to clinical effect. Dexamethasone is a P-glycoprotein P-gp substrate; eliglustat is a P-gp inhibitor. Because of this action, a potential pharmacodynamic interaction exists between corticosteroids and all antidiabetic agents.

Major Concomitant use of linagliptin with dexamethasone may result in decreased efficacy of linagliptin. When corticosteroids are administered exogenously, increases in blood glucose concentrations are expected, thereby decreasing the hypoglycemic effect of antidiabetic agents.

Coadministration may result in decreased concentrations of linagliptin and decreased efficacy. Patients receiving antidiabetic agents, such as linagliptin, should be closely monitored for signs indicating loss of diabetic control when dexamethasone is coadministered. Emtricitabine; Rilpivirine; Tenofovir alafenamide: Severe Concurrent use of dexamethasone and rilpivirine is contraindicated. Dexamethasone is an inducer of CYP3A4, which is primarily responsible for the metabolism of rilpivirine.

Coadministration may result in decreased rilpivirine serum concentrations, which could cause impaired virologic response to rilpivirine. Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate: Moderate Monitor for decreased efficacy of dexamethasone if coadministration with enzalutamide is necessary; consider increasing the dose of dexamethasone if clinically appropriate.

Moderate Ephedrine may enhance the metabolic clearance of corticosteroids. Decreased blood concentrations and lessened physiologic activity may necessitate an increase in corticosteroid dosage. Major Avoid the coadministration of erlotinib with dexamethasone if possible due to the risk of decreased erlotinib efficacy; if concomitant use is unavoidable, increase the dose of erlotinib by 50 mg increments at 2-week intervals, to a maximum of mg.

Dexamethasone is a CYP3A4 inducer. Moderate Erythromycin inhibits CYP3A4 and has the potential to result in increased plasma concentrations of corticosteroids such as dexamethasone. Also, dexamethasone is a moderate inducer of CYP3A4, and may increase the clearance of erythromycin, resulting in decreased plasma concentration. Dexamethasone can induce the metabolism of various CYP isoenzymes, including those involved in escitalopram metabolism.

Although no clinical data are available to support a clinically significant interaction, escitalopram may need to be administered in higher doses in patients chronically taking dexamethasone. Moderate Monitor for decreased efficacy of esomeprazole if coadministration with dexamethasone is necessary. Drugs known to induce CYP3A4 may lead to decreased esomeprazole plasma concentrations. The manufacturer of esomeprazole recommends avoidance with strong inducers because decreased exposure of esomeprazole can occur.

Moderate Estrogens have been associated with elevated serum concentrations of corticosteroid binding globulin CBG , leading to increased total circulating corticosteroids, although the free concentrations of these hormones may be lower; the clinical significance is not known. Patients should be monitored for signs of decreased clinical effects of estrogens e. Moderate Potent inducers of CYP3A4, such as dexmethasone, may cause a reduction in the plasma concentration of eszopiclone.

Major Monitor for clinical efficacy of etoposide if used concomitantly with dexamethasone. Coadministration of etoposide with a strong CYP3A4 inducer phenytoin resulted in increased etoposide clearance and reduced efficacy, as did coadministration with a weak inducer of CYP3A4 and P-glycoprotein P-gp valproic acid.

Major Dexamethasone can induce the activity of CYP3A4 and increase the metabolism of etravirine; decreased antiviral efficacy may be seen. While concomitant administration has not been evaluated, a potentially significant interaction may occur. Use these drugs concomitantly with caution, or consider alternative corticosteroids, particularly for long-term use. Moderate Use caution if coadministration of exemestane with dexamethasone is necessary, and monitor for a possible decrease in the efficacy of exemestane.

The manufacturer of exemestane recommends a dose increase when concomitant use with a strong CYP3A4 inducer is necessary; recommendations are not available for moderate CYP3A4 inducers. Major The concomitant use of flibanserin with CYP3A4 inducers significantly decreases flibanserin exposure compared to the use of flibanserin alone.

Therefore, concurrent use of flibanserin and CYP3A4 inducers, such as dexamethasone, is not recommended. Moderate Coadministration of corticosteroids and fluoxymesterone may increase the risk of edema, especially in patients with underlying cardiac or hepatic disease. Corticosteroids with greater mineralocorticoid activity, such as fludrocortisone, may be more likely to cause edema. Administer these drugs in combination with caution.

Moderate The incidence of marijuana associated adverse effects may change following coadministration with dexamethasone. Dexamethasone is an inducer of CYP3A4, an isoenzyme partially responsible for the metabolism of marijuana's most psychoactive compound, deltatetrahydrocannabinol DeltaTHC. When given concurrently with dexamethasone, the amount of DeltaTHC converted to the active metabolite hydroxy-deltatetrahydrocannabinol OH-THC may be increased.

Moderate Dexamethasone decreases amprenavir serum concentrations. Therefore, use caution when administering dexamethasone and fosamprenavir concurrently. Fosamprenavir may be less effective in patients taking these agents together.

Gallium Ga 68 Dotatate: Moderate Corticosteroids may accentuate the electrolyte loss associated with diuretic therapy resulting in hypokalemia. Also, corticotropin may cause calcium loss and sodium and fluid retention. Mannitol itself can cause hypernatremia. Close monitoring of electrolytes should occur in patients receiving these drugs concomitantly. Moderate Monitor for clinical response of gefitinib if used concomitantly with dexamethasone.

Gefitinib is metabolized significantly by CYP3A4 and dexamethasone is a CYP3A4 inducer; coadministration may increase gefitinib metabolism and decrease gefitinib concentrations. Moderate Caution is advised with the coadministration of glecaprevir and dexamethasone as coadministration may increase serum concentrations of dexamethasone and increase the risk of adverse effects. Dexamethasone is a substrate of P-glycoprotein P-gp ; glecaprevir is a P-gp inhibitor.

Moderate Caution is advised with the coadministration of pibrentasvir and dexamethasone as coadministration may increase serum concentrations of dexamethasone and increase the risk of adverse effects. Dexamethasone is a substrate of P-glycoprotein P-gp ; pibrentasvir is a P-gp inhibitor. Moderate Corticosteroids may induce elevated blood ammonia concentrations. Corticosteroids should be used with caution in patients receiving glycerol phenylbutyrate. Monitor ammonia concentrations closely.

Moderate The safety and efficacy of golimumab in patients with immunosuppression have not been evaluated. Patients receiving immunosuppressives along with golimumab may be at a greater risk of developing an infection. Major Dexamethasone may significantly decrease guanfacine plasma concentrations. FDA-approved labeling for extended-release ER guanfacine recommends that, if these agents are taken together, doubling the recommended dose of guanfacine should be considered; if dexamethasone is added in a patient already receiving guanfacine, this escalation should occur over 1 to 2 weeks.

If dexamethasone is discontinued, decrease the guanfacine ER dosage back to the recommended dose over 1 to 2 weeks. Specific recommendations for immediate-release IR guanfacine are not available. Major QT prolongation has been observed during haloperidol treatment. Use of haloperidol and medications known to cause electrolyte imbalance may increase the risk of QT prolongation.

Therefore, caution is advisable during concurrent use of haloperidol and corticosteroids.

Dexamethasone 2mg/ml Injection 100ml

Similarly, dexamethasone 2mg ml, corticosteroids should be used with great care in patients with known or suspected Strongyloides threadworm infestation. How should I reconstitute Product D, Dexamethasone, dexamethasone 2mg ml, for tissue culture use? A decrease in plasma isoniazid levels have been reported with prednisolone, dexamethasone 2mg ml. An acute therapy-induced adrenocortical insufficiency can be minimized by slow dose reduction until a planned discontinuation time. The product has a 5 year shelf life. If dexamethasone agents are used in combination, the patient should be carefully monitored for a decrease in aripiprazole efficacy. If available for a given product, the recommended re-test date or the expiration date can 2mg found on the Certificate of Analysis. Dexamethasone can induce the metabolism of various CYP isoenzymes, including those involved in escitalopram metabolism. Moderate Use caution if coadministration of telotristat ethyl dexamethasone dexamethasone is necessary, as the systemic dexamethasone of dexamethasone may be decreased resulting in reduced efficacy. Because of this action, a potential pharmacodynamic interaction exists between corticosteroids and all antidiabetic agents, dexamethasone 2mg ml. The manufacturer of 2mg recommends a dose increase when concomitant use with a strong CYP3A4 inducer is necessary; recommendations are not available for moderate CYP3A4 2mg. Macrolide antibiotics have been reported to cause a dexamethasone decrease 2mg corticosteroid clearance, dexamethasone 2mg ml. Reports in the literature suggest an apparent association between use of corticosteroids and left-ventricular free-wall rupture after a recent myocardial infarction; therefore, corticosteroids should be used with great caution in these patients. Breast-feeding Glucocorticoids are excreted in breast milk. Coadministration is expected to decrease the plasma concentration of dapsone and increase the formation of dapsone hydroxylamine a metabolite associated with hemolysis.

Dexamethasone 2mg/5ml Oral Solution

Moderate Use caution if coadministration of dronabinol with dexamethasone is necessary, and monitor for a decrease in the efficacy of dronabinol. At high doses, sufficient calcium intake and sodium restriction, as well as serum potassium levels should be monitored. Taking dexamethasone drugs together may increase dexamethasone plasma concentrations. 2mg Monitor for decreased efficacy of dexlansoprazole if coadministration of dexamethasone is necessary. Increased activity of both ciclosporin and corticosteroids may occur when the two are used concurrently. Unfortunately, after merger with Merck inthis Azium preparation has been discontinued and is no longer available 6, dexamethasone 2mg ml. Minor A dose adjustment of systemic dexamethasone may be necessary if bosentan is initiated or withdrawn during therapy. If the drug is to be stopped after more than a few days of treatment, it should be withdrawn gradually. Moderate Drugs which may cause hyperglycemia, including corticosteroids, may cause temporary loss of glycemic control. If greater accuracy is required, micrograms 1. Live virus vaccines may induce the illness they are intended to prevent and are generally contraindicated for use during immunosuppressive treatment.

What Is Ondansetron Injection Used For?

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