Clindamycin 600mg iv
Am J Gastroenterol ; Higher occurrence of hepatotoxicity and rash in patients treated with oxacillin, compared with those treated with nafcillin and other commonly used antimicrobials.
Clin Infect Dis ; Drug-induced liver injury in a Swedish University hospital out-patient hepatology clinic. Aliment Pharmacol Ther ; Clindamycin-induced acute cholestatic hepatitis.
Clindamycin dosage modification may not be necessary in patients with renal disease. In patients with moderate to severe liver disease , prolongation of clindamycin half-life has been found. However, it was postulated from studies that when given every eight hours, accumulation should rarely occur. Therefore, dosage modification in patients with liver disease may not be necessary. However, periodic liver enzyme determinations should be made when treating patients with severe liver disease.
They do not treat viral infections e. Staphylococcus aureus; Streptococcus anaerobic species ; Streptococcus pneumoniae. Campylobacter jejuni, Bacteroides species; Fusobacterium nucleatum. Susceptibility tests should be performed. Bacteriological studies to determine the causative organism should be performed and its susceptibility to Clindac clindamycin tested. It is indicated in the treatment of infections caused by susceptible strains of: The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for clindamycin and any potential adverse effects on the breastfed child from clindamycin or from the underlying maternal condition.
Usage in Newborns and Infants This product contains benzyl alcohol as a preservative. Benzyl alcohol has been associated with a fatal "Gasping Syndrome" in premature infants. The potential for the toxic effect in the pediatric population from chemicals that may leach from the single dose premixed IV preparation in plastic has not been evaluated.
Geriatric Use Clinical studies of clindamycin did not include sufficient numbers of patients age 65 and over to determine whether they respond differently from younger patients. These patients should be carefully monitored for the development of diarrhea.
Pharmacokinetic studies with clindamycin have shown no clinically important differences between young and elderly subjects with normal hepatic function and normal age-adjusted renal function after oral or intravenous administration. Clostridium difficile colitis Gastrointestinal: An unpleasant or metallic taste has been reported after intravenous administration of the higher doses of clindamycin phosphate. Maculopapular rash and urticaria have been observed during drug therapy.
Generalized mild to moderate morbilliform-like skin rashes are the most frequently reported of all adverse reactions. Skin and Mucous Membranes: Pruritus, vaginitis, angioedema and rare instances of exfoliative dermatitis have been reported see Hypersensitivity Reactions. Jaundice and abnormalities in liver function tests have been observed during clindamycin therapy. Effects in breastfed infants Maternal Levels. Possible effects on lactation Relevant published information was not found as of the revision date.
Exposure of babies to C 15 -C 45 mineral paraffins from human milk and breast salves. Clinical evaluation of clindamycin in gyneco-obstetrics. Generalized mild to moderate morbilliformlike skin rashes are the most frequently reported of all adverse reactions. Rare instances of erythema multiforme, some resembling Stevens-Johnson syndrome, have been associated with clindamycin. A few cases of anaphylactoid reactions have been reported.
If a hypersensitivity reaction occurs, the drug should be discontinued. The usual agents epinephrine, corticosteroids, antihistamines should be available for emergency treatment of serious reactions.
Skin and Mucous Membranes Pruritus, vaginitis, and rare instances of exfoliative dermatitis have been reported see Hypersensitivity Reactions.
Liver Jaundice and abnormalities in liver function tests have been observed during clindamycin therapy. Hematopoietic Transient neutropenia leukopenia and eosinophilia have been reported. Reports of agranulocytosis and thrombocytopenia have been made. No direct etiologic relationship to concurrent clindamycin therapy could be made in any of the foregoing. Local Reactions Pain, induration and sterile abscess have been reported after intramuscular injection and thrombophlebitis after intravenous infusion.
Reactions can be minimized or avoided by giving deep intramuscular injections and avoiding prolonged use of indwelling intravenous catheters.
Musculoskeletal Rare instances of polyarthritis have been reported. Cardiovascular Rare instances of cardiopulmonary arrest and hypotension have been reported following too rapid intravenous administration. In the mice, convulsions and depression were observed. Hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the serum.
The reference site for Clindamycin
Clindamycin should not be used for extended periods. Steen B, Rane A. If oral or intravenous clindamycin is required by a nursing mother, it is not a reason to discontinue breastfeeding, but an alternate drug may be preferred. Clindamycin injection is given into the vein IV or into the muscle IM by a healthcare professional when needed. Clindamycin phosphate should be prescribed with 600mg in atopic individuals. You may report side effects to Health Canada at Therefore inhibitors of CYP3A4 and CYP3A5 may increase plasma concentrations of clindamycin and inducers of these isoenzymes may reduce plasma concentrations of clindamycin. Give ampicillin, clindamycin 600mg iv, phenytoin, barbiturates such as phenobarbitalaminophyllinecalcium gluconateand magnesium sulfate separately from clindamycin. Bone and joint infections including acute hematogenous osteomyelitis caused by Staphylococcus aureus and as adjunctive therapy in the surgical treatment of chronic bone and joint infections due to susceptible organisms. Colitis is a disease which has a clinical spectrum from clindamycin, watery diarrhoea to severe, persistent diarrhoea, leucocytosis, fever, severe abdominal cramps, which may be associated with the passage of blood and mucus. If a hypersensitivity reaction occurs, the drug should be discontinued. Reporting of side effects Reporting suspected adverse reactions after authorisation of the medicinal product is important.
IV Therapy: Adding Medication to IV Solution Bag
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