Continued observation and additional carbohydrate intake may be necessary because hypoglycemia may recur after apparent clinical recovery [see Warnings and Precautions 5.

Amaryl Description Amaryl is an oral sulfonylurea that contains the active ingredient glimepiride. Chemically, glimepiride is identified as 1-[[p-[2- 3-ethylmethyloxopyrrolinecarboxamido ethyl]phenyl]sulfonyl] transmethylcyclohexyl urea C24H34N4O5S with a molecular weight of Glimepiride is a white to yellowish-white, crystalline, odorless to practically odorless powder and is practically insoluble in water. The structural formula is: Amaryl tablets contain the active ingredient glimepiride and the following inactive ingredients: Amaryl - Clinical Pharmacology Mechanism of Action Glimepiride primarily lowers blood glucose by stimulating the release of insulin from pancreatic beta cells.

Sulfonylureas bind to the sulfonylurea receptor in the pancreatic beta-cell plasma membrane, leading to closure of the ATP-sensitive potassium channel, thereby stimulating the release of insulin. Pharmacodynamics In healthy subjects, the time to reach maximal effect minimum blood glucose concentrations was approximately 2—3 hours after single oral doses of Amaryl.

The effects of Amaryl on HbA1c, fasting plasma glucose, and post-prandial glucose have been assessed in clinical trials [see Clinical Studies 14 ]. Studies with single oral doses of glimepiride in healthy subjects and with multiple oral doses in patients with type 2 diabetes showed peak drug concentrations Cmax 2 to 3 hours post-dose.

Glimepiride does not accumulate in serum following multiple dosing. The pharmacokinetics of glimepiride does not differ between healthy subjects and patients with type 2 diabetes. Clearance of glimepiride after oral administration does not change over the 1 mg to 8 mg dose range, indicating linear pharmacokinetics.

Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high or low blood sugar. See also Side Effects section. Your doctor may need to adjust your diabetes medication, exercise program , or diet. Other symptoms of low blood sugar such as dizziness , hunger , or sweating are unaffected by these drugs.

Check the labels on all your medicines such as cough -and-cold products because they may contain ingredients that could affect your blood sugar. Ask your pharmacist about using those products safely.

Should I avoid certain foods while taking Amaryl? Overdose If someone has overdosed and has serious symptoms such as passing out or trouble breathing , call Otherwise, call a poison control center right away. US residents can call their local poison control center at Canada residents can call a provincial poison control center. Symptoms of overdose may include: Notes Do not share this medication with others.

Attend a diabetes education program to learn more about how to manage your diabetes with medications , diet, exercise , and regular medical exams. Learn the symptoms of high and low blood sugar and how to treat low blood sugar. Check your blood sugar regularly as directed. Keep all regular medical and laboratory appointments. Missed Dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule.

It lowers blood sugar by causing the release of your body's natural insulin. How to use Glimepiride Read the Patient Information Leaflet if available from your pharmacist before you start taking glimepiride and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with breakfast or the first main meal of the day, as directed by your doctor, usually once daily. The dosage is based on your medical condition and response to treatment.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.

If you are already taking another diabetes drug such as chlorpropamide , follow your doctor's directions carefully for stopping the old drug and starting glimepiride. Colesevelam can decrease the absorption of glimepiride. If you are taking colesevelam, take glimepiride at least 4 hours before taking colesevelam. Tell your doctor if your condition does not improve or if it worsens your blood sugar is too high or too low.

What conditions does Glimepiride treat? Side Effects Nausea and upset stomach may occur. If either of these effects persists or worsens, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: This medication can cause low blood sugar hypoglycemia. Do not take more tablets than your doctor has prescribed. The usual starting dose is one Amaryl 1 mg tablet once a day If necessary, your doctor may increase the dose after each 1 - 2 weeks of treatment The maximum recommended dose is 6 mg Amaryl per day A combination therapy of glimepiride plus metformin or of glimepiride plus insulin may be started.

In such a case your doctor will determine the proper doses of glimepiride, metformin or insulin individually for you Your dose of Amaryl may need to be adjusted if you change weight, change your lifestyle, or if you are under a lot of stress.

Please speak to your doctor if any of these situations apply to you. If you feel the effect of your medicine is too weak or too strong do not change the dose yourself, but ask your doctor.

If you take more Amaryl than you should If you happen to have taken too much Amaryl or an additional dose there is a danger of hypoglycaemia signs of hypoglycaemia see section 2 and therefore you should instantly consume enough sugar e. When treating hypoglycaemia due to accidental intake in children, the quantity of sugar given must be carefully controlled to avoid the possibility of producing dangerous hyperglycaemia.

Persons in a state of unconsciousness must not be given food or drink. Since the state of hypoglycaemia may last for some time it is very important that the patient is carefully monitored until there is no more danger. Admission into hospital may be necessary, also as a measure of precaution.

Show the doctor the package or remaining tablets, so the doctor knows what has been taken. Severe cases of hypoglycaemia accompanied by loss of consciousness and coma are cases of medical emergency requiring immediate medical treatment and admission into hospital.

It may be helpful to tell your family and friends to call a doctor immediately if this happens to you. If you forget to take Amaryl If you forget to take a dose, do not take a double dose to make up for forgotten doses. If you stop taking Amaryl If you interrupt or stop the treatment you should be aware that the desired blood sugar lowering effect is not achieved or that the disease will get worse again.

Keep taking Amaryl until your doctor tells you to stop. If you have any further questions on the use of this medicine, ask your doctor or pharmacist. Possible side effects Like all medicines, this medicine can cause side effects, although not everybody gets them. Tell your doctor immediately if you experience any of the following symptoms: Allergic reactions including inflammation of blood vessels, often with skin rash which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock Abnormal liver function including yellowing of the skin and eyes jaundice , problems with the bile flow cholestasis , inflammation of the liver hepatitis or liver failure Allergy hypersensitivity of the skin such as itching, rash, hives and increased sensitivity to sun.

Some mild allergic reactions may develop into serious reactions Severe hypoglycaemia including loss of consciousness, seizures or coma Some patients experienced the following side effects whilst taking Amaryl: Rare side effects may affect up to 1 in 1, people Lower blood sugar than normal hypoglycaemia see section 2 Decrease in the number of blood cells: Blood platelets which increases risk of bleeding or bruising White blood cells which makes infections more likely Red blood cells which can make the skin pale and cause weakness or breathlessness These problems generally get better after you stop taking Amaryl Very rare side effects may affect up to 1 in 10, people Allergic reactions including inflammation of blood vessels, often with skin rash which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Amaryl Glimepiride 2mg is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. It may also be used with other diabetes medications. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.

Proper control of diabetes may also lessen your risk of a heart attack or stroke. Amaryl Glimepiride 2mg belongs to the class of drugs known as sulfonylureas. It lowers blood sugar by causing the release of your body's natural insulin. Read the Patient Information Leaflet if available from your pharmacist before you start taking Amaryl Glimepiride 2mg and each time you get a refill.

If you have any questions, ask your doctor or pharmacist. Take Amaryl Glimepiride 2mg by mouth with breakfast or the first main meal of the day, as directed by your doctor, usually once daily. The dosage is based on your medical condition and response to treatment.

Use Amaryl Glimepiride 2mg regularly to get the most benefit from it.

Amaryl M 2mg

Use this medication regularly to get the most benefit from it. If either of these effects persists or worsens, tell your doctor or pharmacist promptly. This document does amaryl contain all possible drug interactions, amaryl m 2mg. It operates by stimulating cialis preisvergleich rezept pancreas to increase the release of insulin helping to control elevated blood sugar levels. If you suffer from any other health conditions or illnesses, amaryl m 2mg. This medicine has been prescribed for you only. If you miss a dose, take it as soon as you remember. 2mg you are using amaryl other medicine including all non-prescription. Glimepiride is completely metabolized by oxidative biotransformation after either an intravenous or amaryl dose. 2mg concomitant amaryl of Amaryl did not 2mg the pharmacokinetics of R- and S-warfarin enantiomers. Notes Do not share this 2mg with others, amaryl m 2mg. If either of these effects persists or worsens, tell your doctor or pharmacist promptly. Discuss the risks and benefits amaryl your doctor. Renal Impairment To minimize the risk of hypoglycemia, the recommended starting dose of Amaryl is 1 mg daily for all patients 2mg type 2 diabetes and renal impairment [see Dosage and Administration 2.

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