Anaphylaxis has been reported. Hepatitis and jaundice have been reported rarely. Treatment of primary herpes simplex infections, including genital herpes: Severely immunocompromised patients or those with impaired absorption: Suppression of recurrent herpes simplex in immunocompetent patients: Higher doses of 1 gram daily have also been used.
Therapy should be interrupted every 6 to 12 months for reassessment of the condition. Prophylaxis of herpes simplex in immunocompromised patients: In such cases episodic treatment of recurrences may be more beneficial; a dose of mg five times daily for 5 days has been recommended, preferably initiated during the prodromal period. Occasional adverse effects after systemic administration include increased serum bilirubin and liver enzymes, haematological changes, skin rashes including erythema multiform, Stevens-Johnson syndrome and toxic epidermal necrolysis , fever, headache, dizziness and gastrointestinal effects such as nausea, vomiting and diarrhoea.
Anaphylaxis has been reported. Hepatitis and jaundice have been reported rarely. Acyclovir is eliminated by renal clearance, therefore the dose must be adjusted in patients with renal impairment. Elderly patients are likely to have reduced renal function and therefore the need for dose adjustment must be considered in this group of patients. Both elderly patients and patients with renal impairment are at increased risk of developing neurological side effects and should be closely monitored for evidence of these effects.
These reactions were generally reversible on discontinuation of treatment. There are no adequate and well-controlled studies in pregnant women. Acyclovir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Acyclovir should be administered to a nursing mother with caution and only when indicated.
There have been no studies to investigate the effect of acyclovir on driving performance or the ability to operate machinery. Possible side effects Side effects are potentially serious and you should report to your doctor or health care professional as soon as possible. These include, but are not limited to: Side effects that usually do not require medical attention: In this way report to your doctor or health care professional if they continue or are bothersome.
Drug interactions There are negative interactions that can occur when Aciclovir is combined with any of the drugs listed above. Phenytoin Fosphenytoin and Aciclovir: Your healthcare provider may need to measure the level of phenytoin in your blood using a blood test and adjust your dose as necessary.
Probenecid can increase the level of Aciclovir in your blood, increasing your risk of acyclovir side effects. Your healthcare provider may need to decrease your acyclovir dosage to prevent this interaction from occurring. Acyclovir can increase the level of Tenofovir in your blood, potentially increasing your risk of side effects.
Your healthcare provider may need to lower your tenofovir dosage to prevent drug interactions. Missed dose Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine the next regularly scheduled time.
Do not take extra medicine to make up the missed dose.
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