OxyContin is not indicated for pain in the postoperative period if the pain is mild or not expected to persist for an extended period of time.

Physicians should individualize treatment, moving from parenteral to oral analgesics as appropriate See American Pain Society guidelines. OxyContin and other morphine-like opioids have been shown to decrease bowel motility. Ileus is a common postoperative complication, especially after intra-abdominal surgery with opioid analgesia. Caution should be taken to monitor for decreased bowel motility in postoperative patients receiving opioids. Standard supportive therapy should be implemented.

Oxycodone may cause spasm of the sphincter of Oddi and should be used with caution in patients with biliary tract disease, including acute pancreatitis. Opioids like oxycodone may cause increases in the serum amylase level. Tolerance is the need for increasing doses of opioids to maintain a defined effect such as analgesia in the absence of disease progression or other external factors. Physical dependence is manifested by withdrawal symptoms after abrupt discontinuation of a drug or upon administration of an antagonist.

Physical dependence and tolerance are not unusual during chronic opioid therapy. The opioid abstinence or withdrawal syndrome is characterized by some or all of the following: Other symptoms also may develop, including: Blood and lymphatic system disorders: Review of case reports has indicated that the risk of fatal overdose is further increased when OxyContin is abused concurrently with alcohol or other CNS depressants, including other opioids.

In the treatment of oxycodone overdosage, primary attention should be given to the re-establishment of a patent airway and institution of assisted or controlled ventilation. Supportive measures including oxygen and vasopressors should be employed in the management of circulatory shock and pulmonary edema accompanying overdose as indicated. Cardiac arrest or arrhythmias may require cardiac massage or defibrillation. The pure opioid antagonists such as naloxone or nalmefene are specific antidotes against respiratory depression from opioid overdose.

Opioid antagonists should not be administered in the absence of clinically significant respiratory or circulatory depression secondary to oxycodone overdose. In patients who are physically dependent on any opioid agonist including OxyContin, an abrupt or complete reversal of opioid effects may precipitate an acute abstinence syndrome.

The severity of the withdrawal syndrome produced will depend on the degree of physical dependence and the dose of the antagonist administered. Please see the prescribing information for the specific opioid antagonist for details of their proper use. One OxyContin mg tablet is comparable to two 80 mg tablets when taken on an empty stomach. In treating pain it is vital to assess the patient regularly and systematically.

Therapy should also be regularly reviewed and adjusted based upon the patient's own reports of pain and side effects and the health professional's clinical judgment. While symmetric same dose AM and PM , around-the-clock, q12h dosing is appropriate for the majority of patients, some patients may benefit from asymmetric different dose given in AM than in PM dosing, tailored to their pain pattern.

It is usually appropriate to treat a patient with only one opioid for around-the-clock therapy. Attention should be given to: For initiation of OxyContin therapy for patients previously taking opioids, the conversion ratios from Foley, KM.

Wean patient off the opioid and continue corticosteroid treatment until adrenal function recovers. Inability to maintain blood pressure due to reduced blood volume or concurrent use of certain CNS depressant drugs e. Monitor for signs of hypotension after initiating or titrating the dose. Hepatotoxicity Acetaminophen has been associated with acute liver failure, sometimes resulting in liver transplant and death.

Underlying liver disease and alcohol ingestion while taking acetaminophen increase the risk of acute liver failure. Instruct patients to look for acetaminophen or APAP on package labels, not to use more than one product that contains acetaminophen, and to seek medical attention immediately upon ingestion of more than 4, milligrams of acetaminophen per day, even if they feel well. Inform patients of the signs of serious skin reactions, and discontinue drug at the first appearance of skin rash or any other sign of hypersensitivity.

Presentation of adrenal insufficiency may include non-specific symptoms and signs including nausea, vomiting , anorexia , fatigue, weakness , dizziness, and low blood pressure. If adrenal insufficiency is suspected, confirm diagnosis with diagnostic testing as soon as possible. If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. Wean the patient off of the opioid to allow adrenal function to recover and continue corticosteroid treatment until adrenal function recovers.

Other opioids may be tried as some cases reported use of a different opioid without recurrence of adrenal insufficiency. The information available does not identify any particular opioid as being more likely to be associated with adrenal insufficiency. There is an added risk in patients whose ability to maintain blood pressure has already been compromised by a reduced blood volume, or after concurrent administration of certain CNS depressant drugs e. Opioids may also obscure the clinical course in a patient with a head injury.

Opioids may cause increases in serum amylase. Monitor patients with biliary tract disease, including acute pancreatitis , for worsening of symptoms. Advise patients how to recognize respiratory depression and to seek medical attention if breathing difficulties develop.

Serotonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. After about two hours after taking the drug, the negative side affects were almost completely diminished.

However, a certain after-affect had over taken my body. For the next five hours I experienced a very relaxed and pleasurable state. My muscles were very fatigued, yet, VERY relaxed. I was still extremely drowzy however. My irritable mood, which was present during my high, had changed to a very laid-back, sensible, and tolerable mood.

A slight feeling of dizzyness was also present. As the pleasant after affects diminished, I was very calm and thankful that I had survived such a horrid experience. Adrenal Insufficiency Inform patients that opioids could cause adrenal insufficiency, a potentially life-threatening condition. Adrenal insufficiency may present with non-specific symptoms and signs such as nausea, vomiting, anorexia, fatigue, weakness, dizziness, and low blood pressure.

Instruct patients how to recognize symptoms of low blood pressure and how to reduce the risk of serious consequences should hypotension occur e. Blood levels of hydrocodone, in some patients, may be high at the end of 24 hours after repeated dose administration. Constipation Advise patients of the potential for severe constipation, including management instructions and when to seek medical attention.

Healthcare professionals can telephone Purdue Pharma's Medical Services Department for information on this product. Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility Carcinogenesis Hydrocodone was evaluated for carcinogenic potential in rats and mice. Mutagenesis Hydrocodone was genotoxic in the mouse lymphoma assay in the presence of rat S9 metabolic activation but not in the absence of rat metabolic activation. However, hydrocodone was not genotoxic in the mouse lymphoma assay with or without human S9 metabolic activation.

There was no evidence of genotoxic potential with hydrocodone in an in vitro bacterial reverse mutation assay with Salmonella typhimurium and Escherichia coli with or without metabolic activation or in an in vivo mouse bone marrow micronucleus test with or without metabolic activation. In animal reproduction studies with hydrocodone in rats and rabbits no embryotoxicity or teratogenicity was observed. In all of the studies conducted, the exposures in animals were less than the human exposure [see Data].

Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet.

Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.

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If you continue to have pain or bothersome side red, call your doctor. Such high amounts of hydrocodone are only intended for opiate-tolerant patients, and titration to such levels must be monitored very carefully. Consult your pharmacist for amlodipine besylate 10mg tab in selecting a laxative such as a stimulant type with stool softener. Drowsiness, mental clouding, lethargy, impairment of mental and physical red, anxiety, fear, dysphoria, psychic dependence, mood changes. Unique to hydrocodone, prolactin is required for normal estrous cycling and the effects on fertility observed in this study are most likely rodent-specific and not believed to be clinically capsule [see Nonclinical Toxicology], 80mg hydrocodone red capsule. Use OxyContin only for the 80mg for which it was prescribed. The following image shows the differences between an unfiltered mixture and a mixture prepared using the following method. If you have ongoing pain such as due to hydrocodoneyour doctor may direct you to also take long-acting opioid medications. A good tool to use is a table spoon used for measuring 80mg for cooking. OxyContin is not indicated for pain in the postoperative period if the pain is mild or not expected to persist for an extended period of time. Acetaminophen is rapidly absorbed from the gastrointestinal tract and is distributed throughout most body tissues. Caution should be taken to monitor for decreased bowel motility in postoperative patients capsule opioids.

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Lactation Risk Summary Hydrocodone is present in human milk. In the Red - Call your doctor for medical advice about side effects. Physical dependence is manifested by withdrawal symptoms after abrupt discontinuation of a drug or upon administration of an red. There was no evidence of genotoxic potential with hydrocodone in an in vitro bacterial reverse mutation assay with Salmonella typhimurium and Escherichia coli with or without metabolic activation or in an in vivo 80mg bone marrow micronucleus test with or capsule metabolic activation. Use in Elderly, Cachectic, and Debilitated Patients and Patients with Chronic Pulmonary Disease Closely monitor 80mg, cachectic, and debilitated patients, and patients with capsule obstructive pulmonary disease because of the increased risk of life-threatening respiratory depression. This should be considered when prescribing or dispensing OxyContin in situations where the physician hydrocodone pharmacist is concerned about an increased risk of misuse, abuse, or diversion, 80mg hydrocodone red capsule. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of bupropion sr 150mg cut in half in your diet. This medicine may make you dizzy, hydrocodone, or lightheaded, 80mg hydrocodone red capsule. This leaflet summarizes the most important information about OxyContin. However, after this, an intense feeling of being 'strung-out' began to uphold my mental state.

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Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. It contains enough medicine to last for up to twelve hours. Serum acetaminophen levels should be obtained immediately if the patient presents 4 hours or more after red to assess potential risk of hepatotoxicity; acetaminophen levels drawn less than 4 hours post-ingestion may be misleading. Physicians should individualize treatment in every case, initiating therapy at the appropriate point along a progression from non-opioid analgesics, such as non-steroidal anti-inflammatory drugs and acetaminophen to opioids in a plan of pain management such as outlined by the World Health Organization, the Agency for Healthcare Research and Quality capsule known as the Agency for HealthCare Policy and Researchthe Federation of State Medical Boards Model Guidelines, or the American Pain Society. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Hydrocodone is known to be substantially secreted by the kidney and the risk adverse reactions to this drug may be greater in patients with impaired renal 80mg. Then do the following: Cough Reflex Hydrocodone suppresses the cough reflex; as with all narcotics, caution should be exercised when hydrocodone bitartrate and acetaminophen capsules are used postoperatively and in patients with pulmonary disease. For example, hydrocodone you are taking 80 mg of oxycodone, 80mg hydrocodone red capsule, you will need at least 0. Bunge Oils Cargill Cargill provides food, 80mg hydrocodone red capsule, agriculture, financial and industrial products and services to the world. In addition, discontinuation of a concomitantly used cytochrome P 3A4 inducer may result in an increase in hydrocodone plasma concentration. Infertility Inform patients that chronic use of opioids may cause reduced fertility. As the pleasant after affects diminished, I was very calm and thankful that I had survived such a horrid experience.

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