Administration of lisinopril blocks the renin-angiotensin-aldosterone axis and tends to reverse the potassium loss associated with the diuretic. In clinical studies, the extent of blood pressure reduction seen with the combination of lisinopril and hydrochlorothiazide was approximately additive. In most patients, the antihypertensive effect of lisinopril and hydrochlorothiazide tablets was sustained for at least 24 hours. Concomitant administration of lisinopril and hydrochlorothiazide has little or no effect on the bioavailability of either drug.
The combination tablet is bioequivalent to concomitant administration of the separate entities. Lisinopril Hydrochlorothiazide The mechanism of the antihypertensive effect of thiazides is unknown. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine. If they continue or are bothersome, check with your doctor.
Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. If you take too much If overdose is suspected, contact your local poison control center or emergency room immediately.
Symptoms of overdose may include dizziness, fainting, and weakness. Check your blood pressure regularly. Keeping your blood pressure under control is important to help lower the risk of heart, kidney, and blood vessel problems.
Report prolonged diarrhea or vomiting to your doctor. To prevent dehydration, drink plenty of fluids unless your doctor directs you otherwise. If you have diabetes, this product may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.
Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. This product may affect your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.
Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Consult your doctor for more details. It is unknown if lisinopril passes into breast milk. Hydrochlorothiazide passes into breast milk, but is unlikely to harm a nursing infant.
Consult your doctor before breast-feeding. Store at room temperature away from light and moisture. Ask your doctor to tell you about the specific harm that may be done to the fetus. Women who are breast-feeding This drug may pass into breast milk and may cause side effects in a child who is breast-fed.
Talk to your doctor if you breast-feed your baby. You may need to decide whether to stop breast-feeding or stop taking this medication. For seniors Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. Allergies This drug can cause a severe allergic reaction.
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