The incidence of serious rash associated with hospitalization and discontinuation of lamotrigine in a prospectively followed cohort of pediatric patients aged 2 to 17 years is approximately 0. One rash-related death was reported in a prospectively followed cohort of 1, pediatric patients aged 2 to 16 years with epilepsy taking lamotrigine as adjunctive therapy. There is evidence that the inclusion of valproate in a multidrug regimen increases the risk of serious, potentially life-threatening rash in pediatric patients.
In pediatric patients who used valproate concomitantly for epilepsy, 1. Serious rash associated with hospitalization and discontinuation of lamotrigine occurred in 0. Approved The risk or severity of adverse effects can be increased when Butenafine is combined with Lamotrigine. Approved The risk or severity of adverse effects can be increased when Butethal is combined with Lamotrigine. Approved, Illicit The risk or severity of adverse effects can be increased when Butoconazole is combined with Lamotrigine.
Approved The risk or severity of adverse effects can be increased when Butorphanol is combined with Lamotrigine. Approved, Illicit, Vet Approved The serum concentration of Lamotrigine can be increased when it is combined with Cabazitaxel. Approved The serum concentration of Lamotrigine can be increased when it is combined with Caffeine. Approved The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium.
Approved, Nutraceutical The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium Acetate. Approved The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium Carbonate.
Approved The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium Citrate. Approved The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium glubionate.
Approved The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium Gluceptate. Approved The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium gluconate. Approved, Vet Approved The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium lactate. Approved, Experimental, Investigational, Vet Approved Calcium lactate gluconate The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium lactate gluconate.
Experimental The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium laevulate. Experimental The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium pangamate.
Experimental The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium Phosphate. Approved The serum concentration of Lamotrigine can be increased when it is combined with Canagliflozin. Approved The serum concentration of Lamotrigine can be increased when it is combined with Candesartan.
Approved The risk or severity of adverse effects can be increased when Candicidin is combined with Lamotrigine. Withdrawn The risk or severity of adverse effects can be increased when Canertinib is combined with Lamotrigine. Investigational The risk or severity of adverse effects can be increased when Capric acid is combined with Lamotrigine.
Experimental The serum concentration of Lamotrigine can be increased when it is combined with Captopril. Approved The risk or severity of adverse effects can be increased when Lamotrigine is combined with Carbamazepine.
Approved, Investigational The risk or severity of adverse effects can be increased when Lamotrigine is combined with Carbinoxamine. Approved The metabolism of Lamotrigine can be decreased when combined with Carbomycin. Vet Approved The risk or severity of adverse effects can be increased when Carfentanil is combined with Lamotrigine. Illicit, Investigational, Vet Approved The risk or severity of adverse effects can be increased when Carisoprodol is combined with Lamotrigine.
Approved The serum concentration of Lamotrigine can be increased when it is combined with Carvedilol. Approved, Investigational The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Casein. Approved The risk or severity of adverse effects can be increased when Caspofungin is combined with Lamotrigine.
Approved The risk or severity of adverse effects can be increased when Lamotrigine is combined with Cerivastatin. Withdrawn The risk or severity of adverse effects can be increased when Cerulenin is combined with Lamotrigine. Approved The risk or severity of adverse effects can be increased when Cetirizine is combined with Lamotrigine. Approved The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Lamotrigine.
Approved, Illicit, Vet Approved The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lamotrigine. Approved, Illicit The risk or severity of adverse effects can be increased when Chlormezanone is combined with Lamotrigine. Approved, Investigational, Withdrawn The risk or severity of adverse effects can be increased when Chloroprocaine is combined with Lamotrigine. Approved The serum concentration of Lamotrigine can be increased when it is combined with Chloroquine.
Approved, Vet Approved The serum concentration of Lamotrigine can be decreased when it is combined with Chlorotrianisene. Investigational, Withdrawn The risk or severity of adverse effects can be increased when Chloroxine is combined with Lamotrigine.
Approved The risk or severity of adverse effects can be increased when Lamotrigine is combined with Chlorphenamine. Approved The serum concentration of Lamotrigine can be increased when it is combined with Chlorpromazine. Approved, Vet Approved The serum concentration of Lamotrigine can be increased when it is combined with Chlorpropamide.
Approved The serum concentration of Lamotrigine can be increased when it is combined with Chlorprothixene. Approved, Investigational, Withdrawn The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Lamotrigine. Approved The serum concentration of Lamotrigine can be increased when it is combined with Cholesterol. Experimental, Investigational The serum concentration of Lamotrigine can be decreased when it is combined with Cholic Acid.
Approved The risk or severity of adverse effects can be increased when Ciclopirox is combined with Lamotrigine. Approved, Investigational The serum concentration of Lamotrigine can be increased when it is combined with Cilazapril.
Approved The serum concentration of Lamotrigine can be increased when it is combined with Cimetidine. Approved The risk or severity of adverse effects can be increased when Cinchocaine is combined with Lamotrigine. Approved, Vet Approved The serum concentration of Lamotrigine can be increased when it is combined with Ciprofloxacin.
Approved, Investigational The serum concentration of Lamotrigine can be increased when it is combined with Citalopram. Approved The metabolism of Lamotrigine can be decreased when combined with Clarithromycin. Approved The risk or severity of adverse effects can be increased when Clemastine is combined with Lamotrigine. Approved The risk or severity of adverse effects can be increased when Lamotrigine is combined with Clidinium. Approved The risk or severity of adverse effects can be increased when Clobazam is combined with Lamotrigine.
Approved, Illicit The serum concentration of Lamotrigine can be increased when it is combined with Clofazimine. Approved, Investigational The risk or severity of adverse effects can be increased when clomethiazole is combined with Lamotrigine. Investigational The serum concentration of Lamotrigine can be increased when it is combined with Clomipramine. Approved, Vet Approved The risk or severity of adverse effects can be increased when Lamotrigine is combined with Clonazepam. Approved, Illicit The risk or severity of adverse effects can be increased when Lamotrigine is combined with Clonidine.
Approved Clopenthixol The risk or severity of adverse effects can be increased when Clopenthixol is combined with Lamotrigine. Experimental The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Lamotrigine.
Approved, Nutraceutical The risk or severity of adverse effects can be increased when Clorazepate is combined with Lamotrigine. Approved, Illicit Clothiapine The risk or severity of adverse effects can be increased when Clothiapine is combined with Lamotrigine. Experimental The risk or severity of adverse effects can be increased when Clotrimazole is combined with Lamotrigine.
Approved, Vet Approved The risk or severity of adverse effects can be increased when Clozapine is combined with Lamotrigine. Approved The serum concentration of Lamotrigine can be increased when it is combined with Cobicistat. Approved The risk or severity of adverse effects can be increased when Cocaine is combined with Lamotrigine. Approved, Illicit The risk or severity of adverse effects can be increased when Codeine is combined with Lamotrigine.
Approved, Illicit The serum concentration of Lamotrigine can be increased when it is combined with Colchicine. Approved The serum concentration of Lamotrigine can be increased when it is combined with Colforsin. Experimental, Investigational The serum concentration of Lamotrigine can be decreased when it is combined with Conjugated estrogens. Approved The risk or severity of adverse effects can be increased when Cordycepin is combined with Lamotrigine.
Investigational The serum concentration of Lamotrigine can be increased when it is combined with Crizotinib. Approved The risk or severity of adverse effects can be increased when Lamotrigine is combined with Cyclizine. Approved The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Lamotrigine.
Approved The serum concentration of Lamotrigine can be increased when it is combined with Cyclophosphamide. Approved, Investigational The risk or severity of adverse effects can be increased when Cyclosporine is combined with Lamotrigine. Approved, Investigational, Vet Approved The risk or severity of adverse effects can be increased when Cyproheptadine is combined with Lamotrigine. Approved The serum concentration of Lamotrigine can be increased when it is combined with Daclatasvir.
Approved The serum concentration of Lamotrigine can be increased when it is combined with Dactinomycin. Approved The risk or severity of adverse effects can be increased when Lamotrigine is combined with Dantrolene. Approved The risk or severity of adverse effects can be increased when Dapiprazole is combined with Lamotrigine. Approved Dapoxetine may increase the orthostatic hypotensive activities of Lamotrigine. Investigational The serum concentration of Lamotrigine can be increased when it is combined with Dasatinib.
Approved, Investigational The serum concentration of Lamotrigine can be decreased when it is combined with Daunorubicin. Approved The risk or severity of adverse effects can be increased when Deramciclane is combined with Lamotrigine. Investigational The risk or severity of adverse effects can be increased when Desflurane is combined with Lamotrigine.
Approved The serum concentration of Lamotrigine can be increased when it is combined with Desipramine. Approved The serum concentration of Lamotrigine can be increased when it is combined with Desloratadine. Approved, Investigational The risk or severity of adverse effects can be increased when Lamotrigine is combined with Desmopressin. Approved The serum concentration of Desogestrel can be decreased when it is combined with Lamotrigine. Approved The risk or severity of adverse effects can be increased when Lamotrigine is combined with Desvenlafaxine.
Approved Detomidine The risk or severity of adverse effects can be increased when Detomidine is combined with Lamotrigine. Vet Approved The serum concentration of Lamotrigine can be decreased when it is combined with Dexamethasone.
Approved, Investigational, Vet Approved The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Lamotrigine. Approved The risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Lamotrigine. Approved, Vet Approved The serum concentration of Lamotrigine can be increased when it is combined with Dextromethorphan.
Approved The risk or severity of adverse effects can be increased when Dextromoramide is combined with Lamotrigine. Experimental, Illicit The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Lamotrigine. Approved, Illicit, Investigational, Withdrawn The risk or severity of adverse effects can be increased when Dezocine is combined with Lamotrigine.
Approved, Investigational The risk or severity of adverse effects can be increased when Diazepam is combined with Lamotrigine. Approved, Illicit, Vet Approved Dichlorophene The risk or severity of adverse effects can be increased when Dichlorophene is combined with Lamotrigine. Vet Approved The serum concentration of Lamotrigine can be increased when it is combined with Diclofenac. Approved, Vet Approved The serum concentration of Lamotrigine can be decreased when it is combined with Dienestrol.
Approved, Investigational The serum concentration of Dienogest can be decreased when it is combined with Lamotrigine. Approved Diethyl ether The risk or severity of adverse effects can be increased when Diethyl ether is combined with Lamotrigine.
Experimental The serum concentration of Lamotrigine can be decreased when it is combined with Diethylstilbestrol. Approved, Investigational The risk or severity of adverse effects can be increased when Lamotrigine is combined with Difenoxin. Approved, Illicit The serum concentration of Lamotrigine can be decreased when it is combined with Digoxin. Approved The risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Lamotrigine.
Approved, Illicit The serum concentration of Lamotrigine can be increased when it is combined with Dihydroergotamine. Approved The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Lamotrigine. Experimental, Illicit The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Lamotrigine.
Experimental, Illicit The serum concentration of Lamotrigine can be increased when it is combined with Diltiazem. Approved The risk or severity of adverse effects can be increased when Lamotrigine is combined with Dimenhydrinate.
Approved The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Lamotrigine. Approved The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Lamotrigine. Approved, Illicit The serum concentration of Lamotrigine can be increased when it is combined with Dipyridamole.
Approved Dixyrazine The risk or severity of adverse effects can be increased when Dixyrazine is combined with Lamotrigine. Experimental The serum concentration of Dofetilide can be increased when it is combined with Lamotrigine. Approved Doramectin The risk or severity of adverse effects can be increased when Doramectin is combined with Lamotrigine.
Vet Approved The serum concentration of Lamotrigine can be increased when it is combined with Doxazosin. Approved The serum concentration of Lamotrigine can be increased when it is combined with Doxepin. Approved The serum concentration of Lamotrigine can be decreased when it is combined with Doxorubicin.
Approved, Investigational Doxylamine may increase the central nervous system depressant CNS depressant activities of Lamotrigine. Investigational Dronabinol may increase the central nervous system depressant CNS depressant activities of Lamotrigine. Approved, Illicit The serum concentration of Lamotrigine can be increased when it is combined with Dronedarone. Approved Droperidol may increase the central nervous system depressant CNS depressant activities of Lamotrigine.
Approved, Vet Approved The serum concentration of Drospirenone can be decreased when it is combined with Lamotrigine. Approved The risk or severity of adverse effects can be increased when Drotebanol is combined with Lamotrigine. Experimental, Illicit The risk or severity of adverse effects can be increased when Lamotrigine is combined with Duloxetine. Approved The risk or severity of adverse effects can be increased when Dyclonine is combined with Lamotrigine.
Approved The risk or severity of adverse effects can be increased when Ecgonine is combined with Lamotrigine. Experimental, Illicit The risk or severity of adverse effects can be increased when Econazole is combined with Lamotrigine. Approved The risk or severity of adverse effects can be increased when Ecopipam is combined with Lamotrigine.
Investigational The serum concentration of Lamotrigine can be decreased when it is combined with Efavirenz. Approved, Investigational The risk or severity of adverse effects can be increased when Efinaconazole is combined with Lamotrigine. Approved The serum concentration of Lamotrigine can be increased when it is combined with Elbasvir. Approved The risk or severity of adverse effects can be increased when Eltanolone is combined with Lamotrigine. Investigational The serum concentration of Lamotrigine can be increased when it is combined with Enalapril.
Approved, Vet Approved The serum concentration of Lamotrigine can be increased when it is combined with Enasidenib. Approved The risk or severity of adverse effects can be increased when Enflurane is combined with Lamotrigine.
Approved, Investigational, Vet Approved The risk or severity of adverse effects can be increased when Entacapone is combined with Lamotrigine. Approved, Investigational The serum concentration of Lamotrigine can be increased when it is combined with Enzalutamide. Approved The serum concentration of Lamotrigine can be increased when it is combined with Ergonovine.
Approved The serum concentration of Lamotrigine can be increased when it is combined with Ergotamine. Approved The metabolism of Lamotrigine can be decreased when combined with Erythromycin. Approved, Vet Approved The risk or severity of adverse effects can be increased when Lamotrigine is combined with Escitalopram. Approved, Investigational The risk or severity of adverse effects can be increased when Estazolam is combined with Lamotrigine.
Approved, Illicit The serum concentration of Lamotrigine can be decreased when it is combined with Estradiol. Approved, Investigational, Vet Approved The serum concentration of Lamotrigine can be decreased when it is combined with Estramustine. Approved The serum concentration of Lamotrigine can be decreased when it is combined with Estriol.
Approved, Investigational, Vet Approved The serum concentration of Lamotrigine can be decreased when it is combined with Estrogens, esterified. Approved The serum concentration of Lamotrigine can be decreased when it is combined with Estrone.
Approved The serum concentration of Lamotrigine can be decreased when it is combined with Estrone sulfate. Approved The risk or severity of adverse effects can be increased when Eszopiclone is combined with Lamotrigine.
Approved Lamotrigine may increase the central nervous system depressant CNS depressant activities of Ethanol. Approved The risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Lamotrigine.
Approved, Illicit, Withdrawn The serum concentration of Lamotrigine can be decreased when it is combined with Ethinyl Estradiol. Approved The risk or severity of adverse effects can be increased when Lamotrigine is combined with Ethosuximide. Approved The risk or severity of adverse effects can be increased when Lamotrigine is combined with Ethotoin. Approved The risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Lamotrigine.
Withdrawn The risk or severity of adverse effects can be increased when Ethyl chloride is combined with Lamotrigine. Infectious adverse reactions included bronchiolitis, bronchitis, ear infection, eye infection, otitis externa, pharyngitis, urinary tract infection, and viral infection.
Respiratory adverse reactions included nasal congestion, cough, and apnea. Safety and effectiveness in patients below the age of 18 years with Bipolar Disorder have not been established. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Based on a clinical pharmacology study in 24 patients with mild, moderate, and severe liver impairment [see Clinical Pharmacology No dosage adjustment is needed in patients with mild liver impairment. Escalation and maintenance doses may be adjusted according to clinical response [see Dosage and Administration 2.
In a small study comparing a single dose of lamotrigine in patients with varying degrees of renal impairment with healthy volunteers, the plasma half-life of lamotrigine was significantly longer in the patients with renal impairment [see Clinical Pharmacology Initial doses of lamotrigine should be based on patients' AED regimens; reduced maintenance doses may be effective for patients with significant renal impairment.
Few patients with severe renal impairment have been evaluated during chronic treatment with lamotrigine. Because there is inadequate experience in this population, lamotrigine should be used with caution in these patients [see Dosage and Administration 2.
Overdose has resulted in ataxia, nystagmus, increased seizures, decreased level of consciousness, coma, and intraventricular conduction delay. Following a suspected overdose, hospitalization of the patient is advised. General supportive care is indicated, including frequent monitoring of vital signs and close observation of the patient. If indicated, emesis should be induced; usual precautions should be taken to protect the airway.
It should be kept in mind that lamotrigine is rapidly absorbed [see Clinical Pharmacology It is uncertain whether hemodialysis is an effective means of removing lamotrigine from the blood. A Poison Control Center should be contacted for information on the management of overdosage of lamotrigine. When pregnant rats were orally dosed at 0. In dams, food consumption and weight gain were reduced, and the gestation period was slightly prolonged Stillborn pups were found in all 3 drug-treated groups with the highest number in the high-dose group.
Postnatal death was also seen, but only in the 2 highest doses, and occurred between days 1 and Some of these deaths appear to be drug-related and not secondary to the maternal toxicity. A no-observed-effect level NOEL could not be determined for this study. Although lamotrigine was not found to be teratogenic in the above studies, lamotrigine decreases fetal folate concentrations in rats, an effect known to be associated with teratogenesis in animals and humans.
There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
There have been reports of decreased lamotrigine concentrations during pregnancy and restoration of pre-partum concentrations after delivery. Dosage adjustments may be necessary to maintain clinical response. To provide information regarding the effects of in utero exposure to lamotrigine, physicians are advised to recommend that pregnant patients taking lamotrigine enroll in the North American Antiepileptic Drug NAAED Pregnancy Registry.
This can be done by calling the toll-free number , and must be done by patients themselves. Information on the registry can also be found at the website http: Because the effects on the infant exposed to lamotrigine by this route are unknown, breastfeeding while taking lamotrigine is not recommended.
Safety and efficacy of lamotrigine, used as adjunctive treatment for partial seizures, were not demonstrated in a small randomized, double-blind, placebo-controlled, withdrawal study in very young pediatric patients 1 to 24 months. Infectious adverse reactions included:
Estrogen-containing oral contraceptives and other drugs such as rifampin that induce lamotrigine glucuronidation have also been shown to increase the lamotrigine clearance of lamotrigine [see Drug Interactions 7 ]. Approved, Investigational Benzac ac 50mg/g pharmaceutical concentration of Lamotrigine can be increased when it is combined with Biperiden. Approved The risk or severity of adverse taros can be increased when Lamotrigine is combined with Levocetirizine. Few patients with severe renal impairment have been evaluated during chronic treatment with lamotrigine. Experimental, taro pharmaceuticals lamotrigine, Illicit The serum concentration of Lamotrigine can be increased when it is combined with Diltiazem. Approved Romifidine The risk or severity of adverse lamotrigine can be increased when Romifidine is combined with Lamotrigine. Lamotrigine pharmacokinetic parameters for adult and pediatric patients and healthy normal volunteers are summarized in Tables 14 and Approved The risk or pharmaceutical of adverse effects can be increased when Adipiplon is combined with Lamotrigine. Approved, Investigational The serum concentration of Lamotrigine can be increased when it is combined with Lapatinib.
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