Then go back to taking it as you would normally. If it is less than 12 hours to your next dose, skip the dose you missed and take your next dose when you are meant to. Do not double the dose.

If you have trouble remembering when to take your medicine, ask your pharmacist for some hints. If you take too much overdose Immediately telephone your doctor or the Poisons Information Centre 13 11 26 or go to Accidents and Emergency at your nearest hospital immediately if you think that you or anyone else may have taken too much Atacand Plus even if there are no signs of discomfort or poisoning. If you take too many Atacand Plus tablets you will probably get a headache, feel sick nausea , dizzy, thirsty and very tired.

Your blood pressure will not be well controlled if you do not. Tell your doctor if you have excessive vomiting or diarrhoea while taking Atacand Plus. You may lose too much water and your blood pressure may become too low. Tell all doctors, dentists and pharmacists who are treating you that you are taking Atacand Plus. Tell your doctor immediately if you become pregnant while you are taking Atacand Plus.

It may affect your baby if you take it during pregnancy. Things you must not do Do not use it to treat any other complaints unless your doctor says to. Do not give this medicine to anyone else, even if they have symptoms that seem similar to yours. Report prolonged diarrhea or vomiting to your doctor.

Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist. Hydrochlorothiazide may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. It may harm an unborn baby. Consult your doctor for more details. Consult your doctor before breast-feeding. Store at room temperature away from light and moisture.

Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.

Although any chloride deficit is generally mild and usually does not require specific treatment, except under extraordinary circumstances as in liver disease or renal disease , chloride replacement may be required in the treatment of metabolic alkalosis.

Dilutional hyponatremia may occur in edematous patients in hot weather; appropriate therapy is water restriction, rather than administration of salt, except in rare instances when the hyponatremia is life-threatening. In actual salt depletion, appropriate replacement is the therapy of choice. Hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazide therapy.

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. Hyperglycemia may occur with thiazide diuretics. Thus latent diabetes mellitus may become manifest during thiazide therapy.

The antihypertensive effects of the drug may be enhanced in the post-sympathectomy patient. If progressive renal impairment becomes evident consider withholding or discontinuing diuretic therapy. Thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia.

Thiazides may decrease urinary calcium excretion. Thi-azides may cause intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism. Marked hypercalcemia may be evidence of hidden hyperparathyroidism. Thiazides should be discontinued before carrying out tests for parathyroid function. Increases in cholesterol and triglyceride levels may be associated with thiazide diuretic therapy.

Impaired Renal Function Candesartan Cilexetil As a consequence of inhibiting the renin-angiotensin-aldosterone system, changes in renal function may be anticipated in susceptible individuals treated with candesartan cilexetil. Similar results may be anticipated in patients treated with candesartan cilexetil. In studies of ACE inhibitors in patients with unilateral or bilateral renal artery stenosis, increases in serum creatinine or blood urea nitrogen BUN have been reported.

There has been no long-term use of candesartan cilexetil in patients with unilateral or bilateral renal artery stenosis, but similar results may be expected. Hydrochlorothiazide Thiazides should be used with caution in severe renal disease. In patients with renal disease, thiazides may precipitate azotemia. Cumulative effects of the drug may develop in patients with impaired renal function.

Impaired Hepatic Function Candesartan Cilexetil Based on pharmacokinetic data significant increases in candesartan AUC and C max in patients with moderate hepatic impairment have been demonstrated. Information for Patients Pregnancy Female patients of childbearing age should be told about the consequences of second- and third-trimester exposure to drugs that act on the renin-angiotensin system, and they should also be told that these consequences do not appear to have resulted from intrauterine drug exposure that has been limited to the first trimester.

These patients should be asked to report pregnancies to their physicians as soon as possible. All patients should be cautioned that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope.

Drug Interactions Candesartan Cilexetil No significant drug interactions have been reported in studies of candesartan cilexetil given with other drugs such as glyburide, nifedipine, digoxin, warfarin, hydrochlorothiazide, and oral contraceptives in healthy volunteers. Because candesartan is not significantly metabolized by the cytochrome P system and at therapeutic concentrations has no effects on P enzymes, interactions with drugs that inhibit or are metabolized by those enzymes would not be expected.

Lithium - Reversible increases in serum lithium concentrations and toxicity have been reported during concomitant administration of lithium with ACE inhibitors, and with some angiotensin II receptor antagonists.

An increase in serum lithium concentration has been reported during concomitant administration of lithium with candesartan cilexetil, so careful monitoring of serum lithium levels is recommended during concomitant use. Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics - Potentiation of orthostatic hypotension may occur. Antidiabetic drugs oral agents and insulin - Dosage adjustment of the antidiabetic drug may be required.

Other antihypertensive drugs - Additive effect or potentiation. Cholestyramine and colestipol resins - Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins. Single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively.

Pressor amines eg, norepinephrine - Possible decreased response to pressor amines but not sufficient to preclude their use. Skeletal muscle relaxants, nondepolarizing eg, tubocurarine - Possible increased responsiveness to the muscle relaxant. Lithium - Generally should not be given with diuretics. Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity. Non-steroidal Anti-inflammatory Drugs - In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.

Therefore, when ATACAND HCT and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained. Carcinogenesis, Mutagenesis, Impairment of Fertility No carcinogenicity studies have been conducted with the combination of candesartan cilexetil and hydrochlorothiazide.

Rats received the drug by gavage whereas mice received the drug by dietary administration. These maximally-tolerated doses of candesartan cilexetil provided systemic exposures to candesartan AUCs that were, in mice, approximately 7 times and, in rats, more than 70 times the exposure in man at the maximum recommended daily human dose 32 mg.

The NTP, however, found equivocal evidence for hepatocarcinogenicity in male mice. Candesartan cilexetil or candesartan the active metabolite , in combination with hydrochlorothiazide, tested positive in vitro in the Chinese hamster lung CHL chromosomal aberration assay and mouse lymphoma mutagenicity assay.

Both candesartan and its O-deethyl metabolite tested positive for genotoxicity in the in vitro CHL chromosomal aberration assay. Neither compound tested positive in the Ames microbial mutagenesis assay or in the in vitro mouse lymphoma cell assay. Candesartan but not its O-deethyl metabolite was also evaluated in vivo in the mouse micronucleus test and in vitro in the Chinese hamster ovary CHO gene mutation assay, in both cases with negative results.

Candesartan cilexetil was evaluated in the Ames test, the in vitro mouse lymphoma cell assay, the in vivo rat hepatocyte unscheduled DNA synthesis assay and the in vivo mouse micronucleus test, in each case with negative results.

When hydrochlorothiazide was tested alone, positive re-sults were obtained in vitro in the CHO sister chromatid exchange clastogenicity and mouse lymphoma cell mutagenicity assays and in the Aspergillus nidulans non-disjunciton assay. Hydrochlorothiazide was not genotoxic in vitro in the Ames test for point mutations and the CHO test for chromosomal aberrations, or in vivo in assays using mouse germinal cell chromosomes, Chinese hamster bone marrow chromosomes, and the Drosophila sex-linked recessive lethal trait gene.

No fertility studies have been conducted with the combination of candesartan cilexetil and hydrochlorothiazide. Pregnancy Pregnancy Categories C first trimester and D second and third trimesters.

Nursing Mothers It is not known whether candesartan is excreted in human milk, but candesartan has been shown to be present in rat milk. Thiazides appear in human milk.

Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. Pediatric Use Safety and effectiveness in pediatric patients have not been established.

No overall differences in safety or effectiveness were observed between these subjects and younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.

Hydrochlorothiazide is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. More than of these patients were studied for at least six months and more than patients were treated for at least one year. Adverse experiences have generally been mild and transient in nature and have only infrequently required discontinuation of therapy. The overall frequency of adverse experiences was not related to dose, age, gender, or race.

In placebo-controlled trials that included patients treated with various combinations of candesartan cilexetil doses of mg and hydrochlorothiazide doses of 6. Other adverse events that have been reported, whether or not attributed to treatment, with an incidence of 0.

Generic Alternative to Atacand Plus 32/12.5mg

These maximally-tolerated doses of candesartan 12.5mg provided systemic exposures to candesartan AUCs that were, in mice, approximately 7 12.5mg and, in rats, more than 70 times the exposure in man at the maximum recommended daily human dose 32 mg, atacand plus 32 12.5mg. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. Prompt medical or surgical treatments may need to be considered if the intraocular atacand remains uncontrolled. You may need medical treatment if you get some of the side effects. Drug Interactions Because candesartan is not significantly metabolized by the cytochrome P system and at therapeutic concentrations has atacand effects on P enzymes, interactions with drugs that inhibit or are metabolized by those enzymes would not be expected. Atacand action is, therefore, atacand plus 32 12.5mg, independent of the pathways for angiotensin II synthesis. Things you must not do Do not use it to treat any other complaints unless your doctor says to. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Doses ranged from 2 to 32 mg candesartan cilexetil and from 6. Candesartan does not bind to or block other hormone receptors or ion channels known where can i buy meclizine be important in cardiovascular regulation. Because of the hydrochlorothiazide plus, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. These maximally-tolerated doses of 12.5mg cilexetil provided systemic exposures to candesartan AUCs that were, in mice, plus 7 times and, in rats, more than 70 times the exposure in man at the plus recommended daily human dose 32 mg. Skin and Appendages Disorders: For hydrochlorothiazide, the most common signs and symptoms observed are those caused by electrolyte depletion hypokalemia, hypochloremia, hyponatremia and dehydration resulting from excessive diuresis, atacand plus 32 12.5mg.

Atacand Plus 32/12.5mg Tablets 30

The safety and effectiveness of using this medication have not been atacand for children. Check your blood sugar regularly as directed and share the results with your doctor, atacand plus 32 12.5mg. To help you remember, take it at the same time each day. If you atacand not understand the instructions on the box, ask your doctor or pharmacist for help, atacand plus 32 12.5mg. In placebo-controlled trials, hypokalemia was plus in 0. Marked hypercalcaemia may be a sign of hidden atacand. Do not stop taking this medication without consulting your doctor. Unless continued AIIRA therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy. Consult your doctor plus breast-feeding. It also helps the body with normal growth, atacand plus 32 12.5mg, 12.5mg is needed to keep your nervous system functioning properly, help produce cellular energy, and make chemical messengers that are involved in mood. If you stop taking Atacand If you stop taking Atacand, your blood pressure may increase again. In 12.5mg patients, ATACAND Buy viagra over counter therapy should be started under close medical supervision; they should be followed 12.5mg for the first 2 weeks of treatment and whenever the dose of candesartan or diuretic is increased. Vitamin B1, also known as thiamine, helps the body convert carbohydrates, fats, and proteins into energy.

Atacand 16 mg

How to take it The usual dose is one tablet plus daily, taken whole with a glass of water. NDC unit of use bottles of Tell your doctor right away if you have any serious side effects, including: It also 12.5mg to relax the blood vessels so that blood can flow more easily. Information last revised May When pregnancy is diagnosed, treatment price of ambien cr without insurance AIIRAs should be stopped immediately, and, if appropriate, alternative therapy should be atacand see sections 4. It must not be given to children less than 1 year of age. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. There are a few exceptions examples are outlined at the end of this page and as always you should consult your physician before switching from a brand name medications to a generic or vice versa. These factors may affect how you should use this medication. Your doctor will check your progress and may want to take some tests e. Limited data are available in regard to overdosage with candesartan cilexetil in humans. Vitamin B1, also known as thiamine, helps the body convert carbohydrates, atacand plus 32 12.5mg, fats, and proteins into energy.

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