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Diamox Tablets mg - Summary of Product Characteristics (SmPC) - (eMC)
Diamox official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.
Fatalities have diamox, although rarely, due to severe reactions to sulphonamides. A precipitous drop in 250mg blood cell elements or the appearance of toxic skin manifestations should call for immediate cessation of DIAMOX tablets therapy.
In patients with pulmonary obstruction or emphysema where alveolar ventilation may be impaired, DIAMOX tablets minocin 100mg 12 capsulas precio aggravate 250mg and bromocriptine 2.5mg tablets be used with caution.
In patients with a past history of renal calculi, benefit should be balanced against the risks of precipitating further calculi. Sulphonamides may potentiate diamox effects of folic acid antagonists. Possible potentiation of the effects of folic acid antagonists, hypoglycaemics and oral anti-coagulants may occur.
Concurrent administration of acetazolamide and aspirin may result in severe acidosis and increase central nervous system toxicity.
When given concomitantly, acetazolamide modifies the metabolism of phenytoin, leading to increased serum levels of phenytoin. Severe osteomalacia has been noted in a diamox patients taking acetazolamide in combination with other anticonvulsants.
There have been isolated reports of reduced primidone and increased carbamazepine serum levels with concurrent administration of acetazolamide. Because of possible additive effects, concomitant use with other carbonic anhydrase inhibitors is not advisable.
By increasing the pH of renal tubular urine, acetazolamide reduces the urinary excretion of amphetamine and quinidine and so may enhance the magnitude and the duration of effect of amphetamines and enhance the effect of quinidine. Acetazolamide may elevate ciclosporin levels.
Acetazolamide may prevent the urinary antiseptic effect of methenamine. Acetazolamide increases lithium excretion and the blood lithium levels may be decreased. Acetazolamide and sodium bicarbonate used concurrently increases the risk of renal calculus formation. Acetazolamide has been reported to be teratogenic and embryotoxic in rats, t diamox 250mg, mice, hamsters and rabbits at oral or parenteral doses in excess of ten times those recommended in human beings.
Although there is no evidence of these effects in human beings, there are no adequate and well-controlled studies in pregnant women. Therefore, Acetazolamide tablets should not be used in pregnancy, especially during 250mg first trimester. Acetazolamide has been detected in low levels in the milk of lactating women who have taken Acetazolamide tablets.
Although it is unlikely that this will lead to any harmful 250mg in the infant, extreme caution should be exercised when Acetazolamide tablets is diamox to lactating 250mg. Less commonly, fatigue, dizziness and ataxia have been reported, t diamox 250mg. Disorientation has been observed in diamox few patients with oedema due to hepatic cirrhosis. Such cases should be under close supervision. Transient myopia has been reported.
Diamox Tablet
These conditions invariably subside upon diminution or discontinuance diamox the medication, t diamox 250mg. Those effects which have been noted include: Rarely, photosensitivity has been reported. During long-term therapy, metabolic acidosis and electrolyte imbalance may occasionally occur. This can usually be corrected by the administration of bicarbonate. This condition invariably subsides upon diminution or 250mg of the medication.
Gastrointestinal disturbances such as nausea, vomiting and diarrhoea. Acetazolamide is a sulphonamide derivative and therefore some side-effects similar to those caused by sulphonamides have occasionally been reported.
These include fever, agranulocytosis, thrombocytopenia, t diamox 250mg, thrombocytic purpura, leukopenia, and aplastic anaemia, bone marrow depression, pancytopenia, rash including erythema multiforme, Stevens-Johnson Syndrome, toxic epidermal necrolysisanaphylaxis, crystalluria, calculus formation, renal and ureteral colic, and renal lesions. Rarely, fulminant hepatic necrosis has been reported. Other occasional adverse reactions include: Interactions[ edit ] It is possible that it might interact with: Other carbonic anhydrase inhibitors — potential for additive inhibitory effects on carbonic anhydrase diamox hence potential 250mg toxicity.
Ciclosporinmay increase plasma levels of ciclosporin.
Hypoglycemicsacetazolamide can both increase or decrease blood glucose levels. Lithiumincreases excretion, hence reducing therapeutic 250mg. Methenamine compounds, reduces the urinary excretion of methenamines. Phenytoinreduces phenytoin excretion, hence increasing the potential for toxicity.
Primidonereduces plasma levels of primidone. Hence reducing anticonvulsant effect. Quinidinereduces urinary excretion of quinidine, hence increasing the potential for toxicity.
Salicylates diamox, potential for severe toxicity. Sodium bicarbonatepotential for kidney stone formation.